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Bad reaction to weed and Tirz??

4 replies3 peopleApr 7, 2026β˜† Follow
Summary

Can weed trigger paranoia, anxiety, or reduced Tirzepatide effects beyond normal munchies?

One long-term daily user described sudden paranoia, anxiety, worsened cold symptoms, loss of appetite suppression, and overeating after smoking on a 5 mg shot day. Another user noted a study showing a trend toward lower GLP-1 levels and changes in insulin with marijuana use. Tirzepatide itself reduced interest in both alcohol and cannabis for that participant. The original poster now plans to stop smoking.

What this discussion establishesStill open

Whether different cannabis strains affect hunger hormones differently

Nothing here is advice.

4 replies Β· 3 people
SharpTimber40archiveopening postApr 7

Daily user for over a decade with no history of paranoia or feeling overwhelmed. On the day of my second 5 mg shot, appetite suppression strengthened after injecting. Spent the day getting things done until I smoked half a preroll before dinner. Cold symptoms intensified, the medication's effects seemed absent, I ate more including some treats, felt less full the next morning, and dealt with strong paranoia and anxiety so I went to bed early. Came across a claim that weed can lower Tirz levels but found no supporting research. Anyone else experiencing anxiety or other issues from weed that go past just getting hungry? Thinking I'll stop smoking and switch to 5 mg THC 5 mg instead.

BlueSignal49archiveApr 7

I traded my pot habit for peptides and that resolved everything 😁

SharpTimber40archiveApr 7
↳ replying to @BlueSignal49

Never in the past dozen years has my herb caused such disinterest in me before yet perhaps this development is for the better.

SlowBeacon94archiveApr 7
↳ replying to @SharpTimber40 (opening post)

I recall research mentioned elsewhere on how cannabis interacts with GLP-1 amounts. It showed a near-significant drop in those levels at p 0.08 plus clear shifts in insulin readings. Since starting Tirz my interest in both alcohol and marijuana has vanished. Now I wonder whether separate varieties like Sativa Indica or mixes affect hunger-related hormones such as ghrelin GLP-1 and insulin in distinct ways.

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