Transition from 15mg Tirz to Tirz+Reta dosage questions for obese male

Does the hunger follow a pattern, like the day or two right before the next shot? If it does, or even if it doesn't, try splitting the dose every 3.5 days at half strength each time or switch to every five days with a lower total amount. You can test schedules on glp1plotter.com. Most people find retatrutide gives weaker appetite control than tirzepatide and works in less direct ways. If you still want strong suppression and aren't getting bad constipation from tirzepatide, cagrilintide could be worth looking at after trying split dosing. It has big effects from very small amounts, so increase extremely slowly. Retatrutide might come later but probably not as the main driver.

Just started adding retatrutide on top of tirzepatide. I'm noticeably hungrier and eating a bit more, yet the scale is still moving down. I'd keep the tirzepatide dose exactly where it is.

You could go the other way and try a starch-based approach instead. I like retatrutide a lot; studies show it keeps working for weight loss even after two years. Tirzepatide plus eloralintide might end up better in trials, but maybe not. I'd move slowly over to retatrutide by itself for a stretch, using both together in the meantime the way you outlined. Once on 8 mg or more of retatrutide, add cagrilintide or eloralintide if more help is needed.

I'm also on 15 mg tirzepatide once a week and curious how this works out for you. Good luck.

Are you still dropping weight on the 15 mg dose, and do you have diabetes? Would you consider a slightly higher tirzepatide amount? I have a relative who was stuck at 15 mg with weight and sugars moving the wrong way. After some discussion she added 1 mg tirzepatide daily on top of her weekly 15 mg shot. It took six weeks but things turned around. She eats clean, cooks, and walks a lot. Because of her diabetes and autoimmune issues I didn't suggest retatrutide. Not sure if that's the long-term answer, but it's working for now. I've stacked them myself as a non-diabetic and it went well. Started at 7.5 mg tirzepatide plus 0.5 mg retatrutide and after three months was on 4 mg retatrutide alone, losing 23 lb in the final month. It works for some people. I'd begin with 1 mg retatrutide for a couple weeks and increase slowly from there.

I'd simply go up to 17.5 mg tirzepatide, stay there, and add 0.5 or 1 mg retatrutide, increasing the retatrutide gradually without lowering the tirzepatide.

Maybe look at the diet again. Without any GLP it should be difficult to eat enough on carnivore to hold your weight. Are you tracking intake? Some carnivore eaters load up on butter and cream. Retatrutide makes me want sugar and starch, so I couldn't stay low-carb or carnivore on it. I used to do multi-day fasts easily but now need small frequent meals.