Filtering Woes

The user reports repeated clogs with multiple 13mm 0.22um filters despite waiting 15-20 minutes after reconstitution and venting the receiving vial. Others suggest the 1ml volume may be too concentrated, that the filters could be hydrophobic rather than hydrophilic, or that needle size is limiting flow. The original poster confirms trying various filters, larger needles, and water tests with no success, and is trying a different filter brand next.

• Clogs occur after only a small amount passes through despite sitting time and venting
• 1ml reconstitution of 10mg tesa is questioned as possibly too thick
• Water push test with larger needle also failed, pointing away from needle size
• Filter material (hydrophilic vs hydrophobic) suggested as possible root cause
• Some filters work intermittently while others do not

Whether the issue stems from concentration/viscosity or from the specific filters being hydrophobic

Whether switching to a different set of 13mm 0.22um filters will resolve the repeated clogs

Nothing here is advice.