CommunityConditions & Comorbidities

GLP's with HRT for those in perimenopause and menopause

9 replies10 peopleMar 20, 2026☆ Follow
Summary

How do women in perimenopause or menopause experience combining GLP-1 medications with HRT for weight management, and do they plan to continue both long term?

Participants report that GLP-1s paired with HRT produce better outcomes for stubborn weight gain and belly fat than either alone. Many describe both treatments as likely lifelong because benefits extend to sleep, mood, energy, inflammation, and metabolic health, and stopping the GLP-1 often leads to regain amid ongoing hormonal shifts. Lifestyle factors like strength training and protein intake are viewed as essential companions rather than replacements. Experiences with different HRT delivery methods vary, with some noting adjustments can temporarily reduce energy.

What this discussion establishesStill open

What happens after long-term pellet HRT use ends or how to adjust doses without losing energy

Nothing here is advice.

9 replies · 10 people
SharpCompass10archiveopening postMar 20

I recently came across a medical article covering studies from Mayo Clinic and Johns Hopkins. It indicated that women struggling with stubborn weight gain and belly fat during peri and menopause got better results when GLP-1s were used together with HRT. For those already on both, do you expect to keep this combination going indefinitely, or do you worry that stopping the GLP-1 will let menopausal weight gain return even if you stay on HRT?

RustFenwick30archiveMar 21

This topic grabs my attention too. Next week I've got a doctor's visit lined up to talk about hormone replacement. All this perimenopause stuff has worn me out.

AmberPebble48archiveMar 21
↳ replying to @SharpCompass10 (opening post)

I believe this is going to be something I stay on indefinitely. Reducing inflammation and supporting my mental well being would be sufficient reasons for me to use it long term.

ClearLantern81archiveMar 21
↳ replying to @SharpCompass10 (opening post)

From my experience hormone replacement therapy has transformed daily life in many ways. Beyond any shift in body mass I've seen better rest emotional balance vitality and sharper focus. I'll keep going with it while doctors say it's appropriate. My view lines up the same for these blood sugar medications. Gains reach past numbers on a scale to include calmer hunger signals quieter eating thoughts and steadier internal chemistry. This feels like steady support for lasting wellness instead of a brief solution. Even so pairing them with habits such as lifting weights eating enough protein getting solid rest and easing tension helps them deliver more. They don't work alone as miracles. If I stop these medications extra weight often returns without other adjustments especially amid hormone changes in midlife. I regard them as ongoing help for body processes much like the hormone therapy.

KeenMeadow35archiveMar 21

In roughly two weeks time I plan on beginning my progesterone treatment and will follow up with details afterward.

SteadyQuill55archiveMar 21

Once I chat with my physician I'll get started on hormone therapy and figure it'll last forever since perimenopause won't ease up it will only shift into full menopause. I can't picture quitting those weight shots because I really like feeling this much lighter.

CopperFenwick68archiveMar 21

My doctors confirmed these pair up well. They have to stay with me for good and they've transformed how things go.

ClearMarble82archiveApr 4

After using one compound for about twelve months, I recently changed over to a different one. My weight has reached the target level so there's no need for further reduction. I'm hoping to connect with females who have maintained hormone replacement therapy over extended periods. From 2018 until 2021 I endured a terrible time during the transition to menopause and experimented with numerous approaches without success. Pellets finally started in 2021. So far eighteen have been inserted at intervals close to thirteen weeks. The reality is these can't continue indefinitely. Now what? During the latest insertion the physician reduced the testosterone dosage. The thyroid medication was also lowered at the same time, leaving me feeling tired with low vitality again. Both adjustments shouldn't have happened together. Certain topics from the discussions here interest me, yet attempting to mention particular terms or the word beginning with p results in blocks and spam labels. This site is rather disappointing.

WarmAlder42archiveApr 5

For more than two years I've been on hormone replacement therapy. Despite my efforts with weight training twice weekly, walking several miles a couple times a week, and tracking my food intake, the pounds just wouldn't shift. This left me really annoyed, even though the therapy had sorted out my menopause symptoms such as trouble sleeping, sudden warmth, and unexpected urges to eat. Once those were under control, I thought I'd experiment with a GLP-1 medication, and it performed exactly as described. In my experience, women who qualify for hormone therapy often see good results combining it with this approach to finally see movement on the scale without much pushback from their system.

ClearWillow59archiveApr 5

Began my hormone replacement through a service but observed almost no changes except the end of hot flashes. Adding a weight loss medication altered my situation dramatically. My physician later gave me proper hormone therapy which worked wonderfully even if the benefits are harder to specify. Still I've reduced most of my menopausal stomach area after including yet another similar drug. Assessing what each one does separately is tough yet they combine nicely. I think keeping up with the hormone treatment along with the GLP type drugs is how things will stay for me.

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GLP's with HRT for those in perimenopause and menopause · ZyraTrack Community