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Hit a wall with retatrutide

4 replies5 peopleApr 9, 2026☆ Follow
Summary

Why has weight loss stalled on retatrutide after 7 weeks and 21 lb drop despite unchanged habits, and what to do next?

The original poster reports a clear stall after steady early loss on a fixed dose and diet. Replies point to normal fluid shifts after glycogen depletion, the need for tighter tracking plus added movement, and trusting the medication's appetite effects while setting explicit deficit and protein targets. Most agree the drug enables loss but does not cause it by itself, and that true plateaus are rare this early.

What this discussion establishesWhere people disagree

Some emphasize stricter measurement and added activity right away while others advise relying more on the drug's effects and weighing less to avoid overthinking

Nothing here is advice.

4 replies · 5 people
BlueLantern35archiveopening postApr 9

So I've reached a plateau with this after about seven weeks. I've dropped twenty one pounds while keeping a calorie deficit and eating plenty of protein. That's decent progress but the scale has been flat or even up a couple pounds over the last two weeks even though my eating has stayed exactly the same. I'm already on a fairly high dose for this stage and don't plan to raise it. Any ideas on why this is happening and what else might help since I still have a lot left to lose?

AmberSignal47archiveApr 9

Tighten up how carefully you track and measure your food while adding more movement. Even small fidgety actions like bouncing your legs or doing arm lifts can help at first, and walk more whenever possible. The medication helps a lot but it only makes weight loss possible, it does not do the losing for you.

ClearSparrow55archiveApr 9

I've gone from four fifty down to two ten. Don't overthink this. Lean on the appetite suppression you are feeling and let the medication handle the main part. With a lot left to lose, set an aggressive calorie deficit goal plus a daily protein minimum so you know you are truly in a deficit, weigh yourself less often to avoid extra stress, and just move more than you used to with cleaning, walks, yoga or lifting, whatever works.

LevelThistle44archiveApr 9

You are seven weeks in and still averaging three pounds a week after a two week lull, or four pounds a week for the first five weeks. You gave no details on your stats, dosing, sides, goals, intake or exercise. The advice is to adjust your mindset to match reality better, and learning can help with that. Specific advice needs specific information.

CopperSignal27archiveApr 9

At seven weeks with no change in calorie intake this is probably just the scale lying or shifts in body fluid balance. When you first drop calories your body uses up liver glycogen that holds a lot of water, so you can lose several kilos of fluid early on. Later the body readjusts and that is likely what is happening now. True plateaus on these medications usually do not happen until around a year in. With twenty one pounds gone the drug is working, but you may need to wait a week or two for the scale to reflect it again. Some of that early loss was fluid rather than fat, which is normal, so the real fat loss rate is probably lower than three pounds a week. You can check waist circumference instead if the scale is not giving useful feedback, or just trust the process if you are eating less than you need.

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