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IGF-1LR3 vs. HGH and all other *morelins

4 replies3 peopleMay 21, 2026☆ Follow
Summary

How does IGF-1 LR3 compare to HGH, DES, PEG-MGF and other peptides for muscle growth and fat loss?

One user reported noticeable muscle gains from a 30-day run of LR3 and argued that IGF should outperform HGH because it is the direct downstream mediator. The same user strongly prefers DES over LR3 for its shorter half-life and higher potency and ranks PEG-MGF even higher. Another participant could not locate DES and is instead weighing LR3 against Tesamorelin, Aicar or leftover HGH. The thread leaves direct head-to-head results and sourcing details largely unaddressed.

What this discussion establishesWhere people disagree

Preference for DES versus LR3 and the relative ranking of PEG-MGF

Still open

Actual fat-loss or muscle-growth outcomes when LR3 is compared directly with Tesamorelin, Aicar or remaining HGH

Nothing here is advice.

4 replies · 3 people
SteadySparrow49archiveopening postMay 21

Anyone here trying out IGF-1LR3? Noticing real changes in fat loss or especially building muscle? How's it stack up against the other compounds in the thread title? Thanks

SlowSignal40archiveMay 21

I tried somatomedin-LR once and added quite a bit of muscle across the 30 days. On paper IGF should beat HGH for growth because HGH only works by making the body release IGF, so using the actual effector makes more sense. Even so I would pick IGF-1 DES over LR3 every time because the 30-minute half-life and tenfold strength feel like the clear winner. I would still put PEG-MGF ahead of DES for pure muscle building, at least until Tren comes back.

SteadySparrow49archiveMay 21

IGF-1 DES is not appearing on any of the lists I checked, only the standard LR3 version. I am trying to decide how it measures up against Tesamorelin and Aicar, or just finishing off the few HGH ampules I have left.

PlainKettle23archiveMay 22

Keeping an eye on this thread. Planning to start a bulk cycle once summer ends and checking out different possibilities.

SlowSignal40archiveMay 22

By the way I figure most people already know PEG-MGF is a lot easier to come by than DES.

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