Community β€Ί Dosing & Titration

Maintenance on Tirz or Reta....thoughts?

20 replies13 peopleJun 10, 2026β˜† Follow
Summary

What maintenance approaches work after losing weight on tirzepatide or retatrutide?

Users report a range of strategies including staying on the original drug at reduced doses, switching compounds to manage side effects like heart rate or sleep, and stacking. Many who lost on tirzepatide prefer it for maintenance because it is viewed as more established, cheaper, and better tolerated long-term, while retatrutide is sometimes added for extra fat loss or energy. Evidence from studies and personal experience is mixed on whether full weight-loss doses are required to prevent regain or if lower doses suffice for most people.

What this discussion establishesWhere people disagree

Whether maintenance requires the same dose used for weight loss or if titration downward is safe and effective for most users

Still open

What happens to people who remain on these medications for a decade or longer

Nothing here is advice.

20 replies Β· 13 people
SlowAnchor19archiveopening postJun 10

Just wondering how folks handle staying steady after dropping a bunch of pounds. People who shed weight on one of these meds, do they stick with it or switch over once they're there? Some mention going one way for the reduction phase and flipping to the other for holding the line. Right now I'm using the first option to keep cutting but have been thinking about the second one once I reach upkeep because of how it might help reshape things. Started out at four hundred, got down to two eighty six and sit at two sixty four now while on seven point five milligrams.

PatientSparrow94archiveJun 10

I've been taking 6mg of Reta for half a year now, and I'm roughly 10 pounds away from my target. Though I intend to move over to Tirz once I reach maintenance phase. The reason is to escape the higher heart rate and reduced HRV that Reta brought on, given that keeping the weight off will likely last a while. Plus with the smaller amounts needed, the extra hunger control seems like it could help.

GreyAlder96archiveJun 10

Outcomes vary based on what someone aims for. After dropping pounds using tirz yet seeking extra help with lipids or fatty liver issues, adding reta works well. Following success with reta, moving over to tirz often brings a slower heart rate at rest along with nicer sleep. I happen to combine sema with reta in my own routine. When focusing on fat loss I introduce reta gradually increasing its amount while keeping the sema level unchanged.

QuietThistle70archiveJun 10

I've kept my weight steady for more than a year. Back when I first started, I dropped fifty-five pounds across six months with Tirzepatide, beginning at one milligram per week and working up to eight. These days I stay level at two point five milligrams weekly. Even after all this time I'm still right where I aimed to be, so settling on a steady amount has suited me well. My reasons for sticking with Tirzepatide, since it suits me, are that the compound has more established research behind it, shows up more easily, gets more nods from physicians, and costs less. I'll probably need to keep using something lifelong to hold my progress, and right now this option comes out ahead in my own weighing of pros and cons. I'm considering shedding another ten to fifteen pounds and adding a bit of Reta to help with that step. This will mark my first time trying Reta. I already have a kit ready and plan to begin with my next injection evening this Saturday.

CopperSignal27archiveJun 11

It seems like the current amount is working nicely for you with the progress so far. Switching over to the other one for the remaining drop or to hold steady probably won't change much, since there's room to go higher if needed to hit the goal. What stands out is that studies indicate keeping the level that got you there is key for not putting it back on, even if some here manage with less. Because there's quite a bit to maintain, experimenting with smaller amounts could work, yet if the scale starts creeping up again, going back higher might be necessary.

SlowAnchor19archiveJun 11

Grateful to those who took time to offer their ideas and thoughts in this spot πŸ’•

ClearWillow59archiveJun 11

I'm taking the pair at once. Upkeep sits near three quarters of the top level for me. Tirz brings a welcome drop in mental chatter and urges. The extra vitality from Reta feels good too. I'll stick with running them together.

RustSignal76archiveJun 11

I've kept using tirz during maintenance for roughly fourteen to fifteen months. Peak usage hit fifteen milligrams right after reaching my target, yet the shots still happen once a week. Levels go up or down anywhere from ten to fifteen milligrams based on how hunger and the scale behaved over the previous seven days. No plans exist to drop tirz since the results stay consistent in my case.

CopperSignal27archiveJun 11

I got started with these agonists once most of the excess body mass was already gone, mainly to get rid of nonstop hunger. Even small doses of the first option brought nasty reactions, while a bigger amount of the second felt much better though the urge to eat still lingered, so I added a third at five milligrams each week. Over almost a year my reading on the scale eased down slowly from seventy eight kilograms to sixty four. Adding half a dose of another one to check whether it helped leaves me unsure so far, yet I manage to eat only when the feeling shows up and the number holds steady. I still watch out for rich foods but wonder if that matters anymore since my appetite now lines up properly with what I take in, unlike back when I carried more weight or lacked these substances.

PlainAlder11archiveJun 11

I'm still seven pounds short of where I want to end up. I'll keep going with this but the amount to take isn't settled. Right now I'm using eight milligrams.

WarmMeadow92archiveJun 11
↳ replying to @CopperSignal27

I wonder if that holds up. Nothing comes to mind about research into ongoing lower amounts after the main phase, though maybe something slipped past me. The trial data shows folks who kept using their reduction level usually avoided putting weight back on. Even so, that doesn't prove they required exactly those levels to hold steady. Quitting clearly leads to regaining, but anything short of that leaves me unsure.

WarmMeadow92archiveJun 11
↳ replying to @SlowAnchor19 (opening post)

Wow, that's amazing progress with your weight drop. I'm close to maintenance myself, just a bit more to reach my target after dropping a lot already. I intend to keep using my current amount of the medication steady for several months up to twelve. The part I'm most excited about is holding steady at my target for a long stretch. I've dropped big amounts before multiple times but couldn't keep it off. So it makes sense to me not to alter the amount right when I arrive at my goal. The research on this medication shows that keeping the level the same helped people avoid regaining. I think smaller amounts might work better eventually, though that's another topic. Since this one is working well for you, there's no reason to change to the other option. I'll stick with this one until it stops working and only then consider combining. Good wishes on your path!

SlowAnchor19archiveJun 11

Thanks for that! Spot on. So far this stuff has been great for me, and all I'm going to do is raise the amount slowly while watching my weight, food consumption, and workouts for no less than the next six months.

PatientTimber45archiveJun 11

This version suits me when trimming down the weight and handling other needs, whereas the primary one fits entirely once goals shift to stability. Really missing my usual rest at night 😴 😴

BlueLedger53archiveJun 11

These days I'm in the maintenance phase too. Each week I use Tirz at either 7.5 or 10 milligrams, and I pick the amount based on how my hunger feels.

QuietFenwick11archiveJun 11
↳ replying to @WarmMeadow92

Findings from the upkeep trials offer hints regarding doses needed to sustain results. The picture included here presents the share of folks who kept off the pounds with the larger medication strengths compared to the smaller strength and the inactive option.

QuietThistle70archiveJun 11

I'm curious how things will turn out after many years or even longer periods of keeping the weight off. Keeping weight off over time has always been where most weight loss efforts fall apart. This kind of medication hasn't been around very long, just a handful of years, and using it widely to drop pounds is newer still. What might happen to people who continue with upkeep doses for ten or twenty years?

WarmMeadow92archiveJun 11
↳ replying to @QuietFenwick11

Thanks for sharing that graph. It shows roughly one fifth to one third couldn't keep their results steady even while staying on the amount used for dropping pounds. So maybe lowering the amount isn't the way to go. Still, it leaves open whether those who succeeded at holding steady on the higher amounts actually required that much to do so. We just can't tell from this.

SlowAnchor19archiveJun 11

I'm in the same spot myself. Appreciative of these medications, yet since beginning with extreme weight issues just like my own case, the word is that ongoing use is required to sustain progress, which makes me eager for any information from extended studies regarding this approach.

GreyAlder46archiveJun 11

My spouse has kept a low Semaglutide amount steady for the past couple of years. I hold my own Tirzepatide level at one point five though. These medications affect me more than most so any increase brings stomach trouble I cannot handle and I doubt that situation will shift. Another thirty three pounds remain before goal yet the scale keeps moving downward after twenty seven have already dropped.

CopperSignal27archiveJun 12
↳ replying to @WarmMeadow92

We don't know for sure yet exactly how much is needed to stay at the new weight, although some here do manage with smaller amounts. I think the amounts used during reduction are what it takes to hold things steady afterward. This comes from certain findings and from grasping the body's responses when loss levels off. At that point the medication's effect on hunger is countering the body's push to regain through greater appetite and lower calorie burn after shedding pounds. That's why loss stops when those are matched. Dropping the amount should then allow regain to start again. I picture this from the chart showing four years on the medication following the first year trial, where weight stays level overall at the doses tested and remains so across that time. It makes sense that this amount keeps things stable on average, and it works across various doses. At this point there's probably little other extended information available. So my conclusion drawn from what's known isn't top-tier trial data, and we really need more targeted research over longer periods. What puzzles me is how studies on holding steady or leveling off define it as under five percent change in the last three months. You might still fit that while taking the highest amount and dropping at the typical pace, so it doesn't seem tight enough to identify true leveling off well, which makes me doubt those findings.

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