Users report significant pain after NAD injections, especially in the buttocks, even when the product is labeled buffered. Common adjustments include using more BAC water for greater dilution, switching to smaller needles or sub-Q thigh or belly sites, and checking or adjusting pH. Several people found these steps helpful while others saw no benefit and stopped. Evidence for NAD's energy effects is viewed as weak by some participants.
What this discussion establishesWhether NAD+ or related compounds like MOTS-c are worth using at all given limited evidence and consistent injection issues.
Still openWhether the NAD products discussed are truly buffered or what the actual pH levels are.
Nothing here is advice.
I recently started NAD and I'm getting quite a bit of pain at the injection site. Put it in my buttocks so sitting is very uncomfortable now. Has anyone else noticed this?
Common suggestions are to check pH, dilute more, or consider IM though that carries more risk. You can also add saline, saline BAC, or regular BAC to the syringe right before injecting to dilute further.
Is it buffered?
Went through a couple of vials a few months ago while trying the mitochondrial protocol. It came from a reseller and was said to be buffered. Hurt every time and didn't do anything for me. Stopped after the MOTS-C part left big hard lumps that took months to go away, and one is still not fully gone.
I was wondering about the total milligrams in that vial along with the volume of bacteriostatic water added. To make the solution flow better for shots I ended up mixing in additional fluid. Switching to a finer needle also lessened the discomfort from the prick. Thigh subcutaneous spots turned out to cause the minimal irritation for me.
NAD+ shot is not worth it in my opinion. After looking at some clinical studies there aren't any clear benefits.
The vial holds five hundred milligrams total. Three milliliters of bac went into mine.
My container was large enough so I went with four milliliters of BAC.
My supply arrives in a ten-milliliter container, so I mix in plenty of fluid to thin it way down. Before each shot I also work in extra bacteriostatic water. Oddly enough the under-skin method causes less discomfort. I always choose the thickest fat spots around my stomach or legs and feel nothing wrong.
I figured maybe I was overreacting about the discomfort from NAD, yet it's reassuring to see others dealing with the same problem. Various approaches like mixing extra liquid into the container or syringe, choosing alternate spots, or preheating the solution all failed to ease things for me. The claim of it being adjusted with buffer seems questionable now. Should this version already cause such issues, the plain one would probably be far worse. Starting the other compound had me anxious due to rumors of similar intensity, though it turned out far milder than this one.
I encountered the identical problem. With 500mg NAD+ I used 3 ml bac. Only half the dose has been taken by me from then on. For sure the following vial gets 6 ml bac added.
I went ahead and checked the acidity level myself. Finding it lower than needed I mixed in some bicarbonate of soda in injectable form straight into the container.
That sounds useful. I'll put both items into my shopping basket once the bacteriostatic water becomes available again at some place. I never looked into the injectable version of sodium bicarbonate yet I bet searching the forum will turn up information. Appreciate the suggestion.
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