ForumDosing & Titration

No effect at all despite 5 mg

11 replies7 peopleMay 4, 2026☆ Follow
Summary

why am I feeling nothing from tirzepatide at 5 mg

Several users note that noticeable effects often begin only at 7.5 mg or higher, which is viewed as the therapeutic range. One person who previously used semaglutide reported needing even larger doses. Another user described clear appetite changes already at 2.5 mg on Mounjaro and steady progress up to 7.5 mg split dosing, while switching later to retatrutide brought back more food noise.

What this discussion establishesWhere people disagree

whether retatrutide is preferable to tirzepatide for appetite control

Still open

whether the current batch actually contained any active compound

Nothing here is advice.

11 replies · 7 people
QuietLedger64archiveopening postMay 4

I'm getting the feeling that I didn't receive any Tirz at all. I'm at 5 mg now and notice no difference whatsoever.

SlowSignal40archiveMay 4

Yeah that happened with me as well. Whenever I asked for some rear entry fun she would answer no yet still get into position. What confusing behavior. I always paid attention to actions rather than the spoken refusal.

GreenMeadow27archiveMay 4
↳ replying to @QuietLedger64 (opening post)

Quite a few folks see no changes before getting to seven point five milligrams or higher. The effective range starts at that level and goes up to fifteen. Were you taking semaglutide earlier? Should that be true, results might need doses exceeding five milligrams.

QuietLedger64archiveMay 4
↳ replying to @GreenMeadow27

No, I have not taken any Semaglutide. I'm hoping it will get better with a higher dose.

GreenMeadow27archiveMay 4
↳ replying to @QuietLedger64

Personally I hold back from evaluating results prior to achieving the effective dosage level. Was your medication acquired from a dependable origin?

PlainAlder11archiveMay 4
↳ replying to @CopperFenwick68

Appreciate the help. Using a translator takes almost no effort. This guy always does that sort of thing if you check what else he's written.

AmberCinder46archiveMay 4

I noticed the lowest amount right away when I began, though it wasn't unpleasant. The next level kept things going smoothly for roughly ten weeks. Then moving up with divided amounts brought almost zero unwanted reactions and kept everything even. I've dropped twenty kilograms over half a year. Lately I moved over to the alternative at three plus three each week, mainly because I was interested to see what would happen. Side effects are gone now yet the hunger signals have increased. This week I'm going with four plus four instead.

SharpAnchor92archiveMay 4

This stuff does other things as well, yet folks find it doesn't cut hunger or those nonstop eating thoughts very much. Its link to the GLP-1 spot comes out far less solid than one similar option, and that option sits below a third choice. Lifters and the like go for it on account of that. Carrying around a bunch of extra weight means the newest pick isn't always the top one.

SlowSignal40archiveMay 4
↳ replying to @CopperFenwick68

I'd gladly agree to that suggestion since this issue has bothered me greatly over time. Back at age thirteen an incompetent physician administered cortisone to treat a high temperature which halted my height increase forever after that point. Just my feet continued developing afterward leaving me stuck at six foot three yet forced to hunt for footwear sized sixteen or seventeen. That awkward waddling appearance frustrates me endlessly. You're correct that switching languages requires little effort yet somehow the button stays invisible on this platform. Maybe it works only through mobile apps. I compose everything on a desktop machine running Chrome so no such tool appears available. Even so it seems reasonable I belong in whatever group that label describes assuming it stems from my earlier comments here.

PlainAlder11archiveMay 4

My mobile device stays unused. Clicking the right mouse button over this message brings up a translation choice.

SlowSignal40archiveMay 4
↳ replying to @PlainAlder11

Wow, cheers for that. Fresh info turns up all the time.

Related discussions

Add your experience

If you have tried it, this topic is still open. Sign in to reply — it takes a minute.