Half-lives / Semaglutide
Semaglutide half-life
Semaglutide stays in your system about 35 days — five half-lives at a half-life of ≈ 7 days (168 h). The computed decay curve is below, with the primary source cited.
Also searched as: sema, ozempic, wegovy, rybelsus.
Source: PubMed 29915923 (semaglutide clinical pharmacokinetics)
Frequently asked
How long does Semaglutide stay in your system?
With a half-life of ≈ 7 days, roughly 97% of a single Semaglutide dose is cleared after five half-lives — about 35 days. Repeated dosing accumulates and takes correspondingly longer to clear.
What does a ≈ 7 days half-life mean in practice?
Every 7 days, the remaining amount halves: 100% → 50% → 25% → 12.5%, and so on. The curve above plots exactly this decay for a single dose.
Where does this Semaglutide half-life number come from?
PubMed 29915923 (semaglutide clinical pharmacokinetics). We cite a primary source for every half-life we publish and version every change.
Related: Semaglutide reconstitution calculator · Semaglutide dose charts
Related half-lives
Other GLP-1 & incretin agonists — how long each stays active:
Guides mentioning Semaglutide
See your own estimated levels
The Zyra Track app plots this curve from the doses you actually log — accumulation, overlaps, and all. Free during the founding period.
Zyra Track is a research and educational utility. Nothing on this page is medical advice, a dosing recommendation, or an endorsement of any compound. We never sell or source compounds and refuse sourcing questions. Consult a qualified clinician for decisions about your health.