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Peri, Tirz, night sweats and heartburn?

9 replies8 peopleAug 20, 2026β˜† Follow
Summary

Does tirzepatide change night sweats during perimenopause and how does it affect heartburn or reflux?

One user reports that night sweats vanished completely after the first injection despite ongoing hot flashes, while heartburn increased after moving to a higher dose. Others note reflux either improved on tirzepatide after weight loss or required separate management with PPIs or antacids. Several mention the medication's effect on gastric emptying as a factor in reflux, and some found symptoms eased over time or with added compounds.

What this discussion establishesStill open

Whether the sudden end to night sweats is a common or lasting effect of tirzepatide

Nothing here is advice.

9 replies Β· 8 people
SharpPebble83archiveopening postAug 20

I've only been at this ten weeks after doing plenty of reading ahead of time and have dropped fifteen pounds. Started through telemed at 1.5 for two weeks and had no side effects besides not feeling constantly hungry. Switched to 2.5 for three weeks instead of going straight to three like the doctor suggested, then hunger came back strong. Looking back it was probably just my cycle but it took three weeks to realize that. Now at 3.0 everything feels fine except the heartburn has gotten worse. The last two shots used filtered medication and I adjusted for overfill at point eight with a thirteen millimeter filter, just noting that. Coming up on my third cycle since the first shot. I've dealt with perimenopause for years and haven't woken up drenched once since that initial injection. Hot flashes are still there but the night sweats have basically disappeared so I no longer change the sheets daily. Has anyone else noticed this? It seems pretty remarkable and when I mentioned it to my primary he barely reacted. Also since going up

GreyHarbour88archiveAug 20

I'm also in peri and have used tirz more than a year now. Reflux has actually decreased for me while on it though my family deals with it a lot. Generic omeprazole from Walmart works fine for daily use.

SharpPebble83archiveAug 20
↳ replying to @GreyHarbour88

I'm already on the generic version of that. When symptoms get bad it stops helping. This issue only started in the past two weeks and came with a fresh bottle that was prepared then.

BrightSparrow36archiveAug 20

Omeprazole works. Also think about adding daily kpv.

CopperSignal27archiveAug 20

Reflux is probably best handled directly with a proton pump inhibitor such as omeprazole which you can get over the counter. Ongoing reflux can damage the esophagus and feels miserable. Any long-term concerns with the medication are likely smaller than the risks from leaving reflux untreated. Weight loss itself often fixes reflux so once the pounds come off it may stop even while still using the glp. I needed high-dose ppis for ten years until the weight came off and then no longer required them. Standard steps like smaller meals, skipping liquids during meals, and avoiding food or drink late in the day can help since lying down makes it worse. These glp medications slow stomach emptying and alter muscle movement which raises reflux risk but that tends to lessen after several months just like other stomach side effects.

SteadySparrow75archiveAug 20
↳ replying to @BrightSparrow36

Exactly. My doctor wanted five but I began at 2.5 and vomited the first night plus had heartburn and reflux for days afterward. Later I tried kpv and while I probably just adjusted to the tirz I think the kpv helped a lot with the stomach problems. I'm definitely a fan of it.

PatientMeadow76archiveAug 20

I had been taking omeprazole but after losing weight on tirz I tapered off over a few months and no longer need it. Now I reach for an occasional over-the-counter antacid maybe once a month at most.

QuietCinder20archive4d

In my role as a physician these issues always come across as extremely concerning. They would stand out as my main worry if brought up during a patient visit. I have patients head over to a digestive specialist or some other medical expert. Medicines only get discussed when I inquire about them. People skip giving too much information and instead briefly note the problems along with their timeframe in a single sentence so I can take charge of the discussion. This happens the very same day.

↳ replying to @QuietCinder20

Nahh, I'm good, but thanks nonetheless... 😎 πŸ‘

NorthWillow72archive4d

Antacids never ease my discomfort in the slightest. It's pointless, much like aiming urine at a wildfire, my friend. These stomach troubles existed well before any weight loss shots. Stopping the acid blocker always brought the problems right back once it left my body. The physician said to keep using it instead of stopping, since avoiding the pain and possible harm from excess acid makes more sense. I've used it steadily for fifteen years now, and that probably explains why another permanent treatment like the weight one never bothered me. Your healthcare setup over there must be really cautious when something as minor and fixable as occasional acid reflux is enough to cause concern.

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