Severe anhedonia with peptides

The only time I've had this was with Tirzepatide, and even at a low dose of 1.5. It started showing up at 2.5, so I lowered it due to that plus stomach problems. Anhedonia sucks, I've dealt with it previously. I think low dopamine is behind it. Maybe try Semax to offset it – that worked for me alongside the Tirz.

I should check into this more, since I haven't come across it with other peptides either. Anhedonia does hit me on Tirz, and nothing I've tried really counters it. It's tough to start tasks, but once I get going I usually feel okay about it. Lost pleasure in lots of stuff I used to enjoy. Hoping it gets better now that I'm at goal weight and reducing the dose.

I usually claim no sides from Reta, but maybe this is one. Been a bit low lately, which I mostly put down to gaining weight and confidence taking a hit. Libido's been way down the last year, and worse since starting Reta. Considering checking testosterone, but in Belgium they ignore it unless it's really bad. Not sure if starting T is wise anyway. Tiredness is constant, but that predates Reta. Weight loss has helped some, at least giving me energy to run again.

For myself, I'm probably feeling more down lately because of the peptides... Though it suits me since I tend to run high energy to the point of distraction. I don't get depressed or really sad, so this calming effect feels like a plus from the peptide routine.

Reta impacts dopamine levels. That's why it's aiding with drug addiction and alcoholism. Probably hits some people harder than others.

Makes me wonder how much of that anhedonia comes from the world being messed up these days?

After going through a bunch of user reports, it looks like a small percentage of folks can get pretty bad anhedonia from BPC 157 or TB500 or the combo. Watch out with them if you're affected.