CommunityFood & Appetite

Sweet tooth increases with use of tirzepatide

12 replies12 peopleSep 28, 2025☆ Follow
Summary

Why do some people get stronger sweet cravings on tirzepatide or retatrutide instead of reduced appetite for sweets?

Users report mixed effects: several notice new or stronger cravings for sweets especially at lower doses or when under-eating carbs, while others lose interest entirely once they reach higher doses. Protein shakes, bars, or yogurt with fruit are mentioned as ways to satisfy the urge without derailing protein goals. Some attribute persistent cravings to insufficient dosing or individual brain-gut responses rather than simple willpower.

What this discussion establishesWhere people disagree

Whether cravings are mainly a dosing issue, a temporary adjustment phase, or a real gut-brain effect that willpower cannot override

Still open

Whether the increased sweet tooth reliably fades with time, higher doses, or switching medications

Nothing here is advice.

12 replies · 12 people
PlainBeacon37archiveopening postSep 28, 2025

Why is this happening? I began tirzepatide at 2.5 mg per week about six or seven weeks ago and have now increased to 3.5 mg weekly. People keep saying tirz should cut the desire for sweets, yet I'm seeing the reverse. Often the only foods that appeal are sweet ones. I usually manage not to act on it, but the change feels odd. Hoping it eventually passes.

BrightMeadow15archiveSep 29, 2025
↳ replying to @PlainBeacon37 (opening post)

While still increasing my tirz dose, past weight-loss efforts showed me that chasing sweets left me short on protein. A chocolate protein shake satisfied the sweet urge and supplied protein, which actually ended the craving.

WryCompass39archiveSep 29, 2025

I have no cravings at all. This sounds like your brain playing tricks.

RustLantern99archiveSep 29, 2025

Tell yourself you can have all the sweets you want once you hit more than 150 g of protein each day.

BrightMeadow15archiveSep 29, 2025
↳ replying to @WryCompass39

We should be careful with that view. How many times have people claimed willpower alone is enough for weight loss, as if it were all in our heads? The gut-brain connection is still poorly understood.

IronThistle42archiveSep 29, 2025
↳ replying to @BrightMeadow15

I agree with the view that cravings disappear completely. Mine are gone. I followed the standard titration schedule from 2.5 to 5 mg after four weeks. The original poster may simply be on too low a dose.

AmberWillow79archiveSep 29, 2025

I don't know why this occurs, but a friend who never liked sweets now craves them after starting. She has lost weight and her health markers are fine. It might relate to eating too few carbs, since that is when I personally start wanting them.

SlowLantern99archiveSep 29, 2025

I never had a particularly strong sweet tooth, but after switching to reta early this year I suddenly developed a serious one.

WrySparrow78archiveSep 29, 2025

My sweet tooth has mostly disappeared since starting reta. It is much easier to skip dessert now.

SharpCompass15archiveSep 29, 2025

My experience is only with reta. I still have some interest in sweets, but now one bite or a small piece is enough. I tend to look for something sweet when I have under-eaten, whether from fasting or simply lacking hunger. Healthier sweet choices like protein shakes no longer appeal to me at all.

QuietAlder20archiveSep 30, 2025
↳ replying to @SlowLantern99

This gives me another reason to stay on the highest tirz dose instead of moving to reta. I feel the sweet-tooth urge has been quieted.

WarmKettle81archiveNov 1, 2025
↳ replying to @PlainBeacon37 (opening post)

You need to reach at least 5 mg before you are at a therapeutic dose.

LevelKettle84archiveNov 9, 2025

I have noticed a clear rise in wanting sweets as my tirz dose has increased. I used to ignore it and stick to my planned meals, yet the thoughts would not stop until I ate something sweet even when already full. Built protein bars or a protein-yogurt-fruit shake now handle the urge, so that is what I turn to.

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Sweet tooth increases with use of tirzepatide · ZyraTrack Community