Tirz and sleep apnea

Not enough weight has come off yet to judge whether snoring has changed and my partner has not noticed anything either. Falling asleep has been harder since starting reta so magnesium and cherry extract are being used for that. Still, mornings feel less exhausted than before. The tirz and SA reports are interesting.

A quick search showed that tirzepatide is the first medication approved specifically for moderate to severe obstructive sleep apnea in adults with obesity. Weight loss remains the biggest driver in lowering SA.

If it works the details do not matter much.

Every mask option from the health service has been tried and they all get fought off during sleep.

It probably does not disappear once present. That is unfortunate but seems to be how it goes.

That is great news.

Keep going. Hope the machine can be left behind.

Thanks. The target weight has been adjusted and another attempt will be made. Starting weight was 335 and reached 210 recently, but sub-200 may be needed to stop using the machine. Good luck with your own effort.

Any weight reduction should help. Sleep actually got worse on reta along with heart rate changes that prompted a return to mostly tirz. The CPAP remains difficult to tolerate at night despite using a favored mask. It gets used during computer time instead because it helps shift into a calmer state. A septoplasty was done recently and a special side-sleeping pillow was ordered from overseas. It is a long process.

Over 100 pounds lost yet OSA continues because of a naturally small airway. A recent test still showed nearly 50 episodes an hour. The same issue appears in a child so testing is being considered. Hoped tirz would resolve it but that has not happened. A particular pillows-style mask works well for sleep on most nights.

We seem to share some history including gastric bypass. Recent study shows AHI at 9, improved from 35 before the medication. Still not resolved and an airway factor may be involved. A full-face mask is used because mouth breathing prevents pillows style. Taping the mouth once caused a panic attack so that was stopped. More loss and another study are planned.

That is worth considering. Loss will be tracked over the next two weeks to decide next steps.

True, the standard approach was being followed without question. Loss will be watched for a few weeks to check for a plateau before any increase.

If progress continues there is no reason to change. With a roughly five-day half-life it takes about four weeks for levels to build up fully. A 2.5 mg dose would reach nearly 4 mg accumulation by then.