Underdosed Tirz?

The original poster switched from semaglutide to a 2.5 mg dose of tirzepatide reconstituted with 300 units and experienced only extreme body soreness on day two with no other effects. Replies note that most batches test at or above label strength, that soreness is atypical for GLP-1 drugs and may suggest infection risk, and that prior semaglutide use can blunt new side effects. One user reports needing 5 mg to notice appetite changes after switching.

• Body soreness after injection is not a standard GLP-1 side effect and may indicate contamination or infection.
• Prior semaglutide use often reduces noticeable effects when starting tirzepatide at 2.5 mg.
• Appetite suppression sometimes appears only after raising the dose to 5 mg.
• COAs are not always easy to locate for a specific lot number.
• Most tested batches meet or exceed the advertised dose.

Whether the reported soreness points to an unsafe product or is unrelated to the medication.

Whether the specific batch was underdosed or matched its label.

Nothing here is advice.