Who takes Jardiance?

I have taken Jardiance together with metformin and Reta for roughly six months. I was already at my target weight when I added it. The clearest difference showed up in my blood work where insulin readings dropped further. I am optimistic about possible liver and kidney protection though those values were already in range so it is hard to tell what it might have prevented.

I have not tried it yet but I am considering adding Jardiance mainly to bring my blood pressure down.

Metformin did not lower death rates in people with prediabetes so its anti-aging reputation may be overstated. I suspect something similar applies to Jardiance though animal data on this class looks more encouraging for lifespan at least in male mice. That still makes it interesting enough that I plan to restart the supply I already have. I had no side effects the first time around.

Taking more diabetes medications together raises the chance of low blood sugar reactions especially after spikes and when using the newer GLP versions with stronger GIP activity. People who already spike higher after meals can then drop lower afterward. Someone I know on Jardiance and metformin added one of the GLPs and had a couple of dizzy spells that were managed at home. Jardiance also increases sugar in the urine so urinary tract infections remain a concern. The GLP drugs seem to achieve many of the same effects including mitochondrial improvements. Still worth monitoring closely once you enter polypharmacy territory.

Jardiance combined with GLP drugs has been very helpful for people with diabetes because both the kidneys and heart respond well. I would still get it through my doctor so regular blood work can be done.

I spotted six main ways these two groups of blood sugar drugs stand apart from each other.

I take it. For someone with diabetes who is only on metformin this option can be somewhat better because it gives clearer protection for the kidneys and heart. It may also produce a modest amount of extra weight loss by causing glucose loss in urine. People who follow very low carbohydrate or fasting approaches might not like the mechanism since it works by excreting glucose. Feeling lightheaded can occur for that reason. Nighttime urination often increases at first but settles down for most within a week or two. Staying hydrated and keeping electrolytes balanced matters. The UTI risk appears lower than early concerns suggested. Without insurance coverage the monthly cost is high for users in the US.

I take it too. Be ready to urinate more often.

I should also note that SGLT2 inhibitors have been linked to a small rise in ketoacidosis risk among diabetics though the increase is modest and the reason is not fully clear.

I take Jardiance because it was prescribed after a cardiac arrest. It is meant to help with my reduced heart pumping strength. So far the ejection fraction has moved from 35 to 45 and I hope it reaches 50. The normal range starts at 55.

Here is a comparison of Jardiance versus GLP drugs for various health effects. Whether one or both are preferable depends on an individual's medical background.

I came across a detailed analysis exploring how these glucose cotransporter blockers might influence artery hardening. The condition stands out as a leading driver of heart related illness and death, stemming from fat deposits, inner vessel lining troubles, swelling, and oxygen related cell harm. These compounds first aimed at managing adult onset diabetes.