CopperSignal27

Have you lost any weight at that low reta dose? If not much, it might be simpler to just increase the reta first. Not sure how you could re…

That's basically what they were made for, long-term management of obesity or diabetes. Their real strength is sustaining the loss over time…

Starting out with a single weekly intake feels easiest, and breaking it into parts only comes up when something needs fixing. I can think o…

Others have said similar. Down 107 pounds and not gaining means the tirz is still working even if it feels like it stopped. After a year it…

It's hard to predict how any one person will respond to these drugs for side effects or for appetite and weight-loss benefits. The doses yo…

Nausea, vomiting, diarrhea and constipation are the most frequent side effects across all GLPs. They can show up for no clear reason, usual…

My use of these drugs began mainly to hold steady after dropping seventy kilos and keeping that off for twelve months, even though hunger n…

The strongest evidence against tolerance with continuous use comes from long-term follow-ups where weight loss stayed flat for four years o…

What these GLP drugs do in people is a bit strange because they don't seem to cause large overall changes. In animal studies they clearly a…

That's the worry. A rodent study gave semaglutide in on-off cycles on a high-fat diet and the animals regained weight during off periods, t…

I was assuming the 400 pounds was more recent than 2016 so the effect is probably less than if it had been last year. Maybe 330 is a more r…

It depends on weight history. If someone has been overweight long term, treating it as a short fix usually fails because weight tends to re…

It seems there's a complication worth noting even if I'd rather not mention it, since the initial mass ought to be taken from before any re…

It would be interesting to locate some study that backs the claim of eating extra calories leading to greater fat reduction. That notion se…

It sounds like you respond very well to semaglutide, so I wouldn't worry too much about switching. It hasn't been studied directly, but peo…

Thanks for that. It's something I've been curious about but my own research didn't go that far. The patent info is pretty convincing that d…

I lost 70 kg three years ago. Two years ago I started semaglutide but had many side-effects even at low doses for a year, then switched to …

Blood concentrations reach their highest point about a day after each injection, meaning the lowest amounts appear right before the followi…

No one has directly measured energy expenditure in humans taking reta, so all the usual claims are estimates or taken from animal work wher…

I checked all the reference links thoroughly but couldn't find any source for the 25-30 mg doses mentioned. The only mention came from a bl…