Users report elevated enzymes during reta use often tied to rapid weight loss rather than direct drug effects, with suggestions like more healthy fats, fiber, hydration and slower loss to support bile flow. Several stress seeing a doctor for ultrasound and full labs since mild elevations may settle on their own or need monitoring. The original poster shared borderline results with no major symptoms while eating high protein and moderate fat. Advice on supplements and whether to pause the medication remains mixed.
What this discussion establishesWhether forum medical discussions amount to illegal advice or remain protected conversation
Still openWhether the original poster should stop reta or if levels will normalize while continuing
Nothing here is advice.
Hi everyone, I began reta in February but the last two months my gallbladder and liver enzymes have all risen. Do I need to quit the medication to fix it or does anyone have ideas for bringing the levels down and easing possible bile blockage
Tirz did the same thing to me yet it settled around month three or four
This looks like the usual bile acid bottleneck. Plenty of hydration, more dietary healthy fats such as eggs olive oil and avocados, extra fiber, no more than two to three pounds lost per week, skip fried foods, and get some exercise. I changed greasy to fried because that seems like clearer guidance.
What exactly do the labs read and how much fat are you taking in. Low fat diets during weight loss can stress the gallbladder since it stops emptying properly. The type of fat does not matter much for getting the gallbladder to contract. I just had a prime NY strip and will call that medicine for my gallbladder.
Cottage cheese works well if you need an easy way to add healthy fats. I calculated that I ate one point six gallons last month and still dropped fifteen pounds while getting extra protein too.
Fast weight loss often leads to gallbladder trouble
Has a doctor checked this already. Reta and similar GLPs can rarely cause real liver toxicity though minor enzyme bumps are more common and sometimes settle if you keep going. An expert needs to decide on stopping or not. You did not say how high the numbers are or which enzymes so hard to tell. Slightly over is usually minor but three to five times normal is more serious. There were six toxicity cases in Victoria Australia recently thought to be from a contaminant in grey market reta though no details on what it was. You seem to be in the US so probably unrelated but worth noting. Liver patterns usually split into cholestatic with raised bilirubin which matches what you describe though gallbladder blockage is not the typical cause.
Maybe I'll start the barbecue this afternoon because of my gallbladder remedy.
That sounds good. Might do the same tonight with a baked potato. I also have two racks of ribs going on the pellet grill tomorrow around eleven at two twenty five degrees.
Goon the pellet grill. Bruh
I type without watching the keys and skip fixing anything that does not get a red underline from spell check
Yes this can happen with fast weight loss and reta might add to it. Gallstones are a known risk during quick loss so the drug itself may not be directly harming the liver. Which enzymes are up matters. AST ALT differ from alkaline phosphatase GGT and bilirubin which point more to bile trouble. Since it has lasted two months get it checked instead of trying to fix numbers alone. An abdominal ultrasound is an easy first step. You might not need to stop reta for good but loop in your doctor especially if loss has been very fast. Avoid crash dieting as that can worsen stones.
Just noting the trouble seems tied to dropping pounds quickly instead of any direct reaction from the medication itself and the pointer leads back to the starting piece.
Talk through the lab results with your physician first. We can share studies and stories but none of us can give medical advice and it is illegal anyway.
One more thing I forgot to ask. Any symptoms besides the lab numbers. Speaking with a doctor is sensible on its face. The rest drifts further from solid ground. Medical talk here does not equal practicing medicine. The original poster is from Canada while most others are in the US so First Amendment protections apply. This is no different from other medical threads the forum has hosted. Three other gallbladder threads already exist with similar info.
It is definitely not illegal to offer medical advice though it gets nuanced for certain professions like teachers where it might seem unethical and risk discipline especially around mental health or minors.
See your physician they can run a liver panel and order an ultrasound. Also worth checking other medications and hormones you might be using. Hope this helps.
I have no issue with people doing their thing. Personally a nice cookout on the grill gets me excited in the same manner, chuckling.
I am not cutting weight or in a deficit right now. I use reta for chronic food noise and to stop binge eating after an aggressive cut in January. No symptoms except feeling light headed or dizzy if I stand too fast. Bilirubin total twenty umol per L, potassium five point four, GGT forty six which is just over the normal under forty four, ALT fifty seven over normal under thirty six, AST fifty three over normal under thirty. Amylase and lipase are high normal but not above. I eat high protein no fried foods though weekends have more sugar and I have always binged then. I am not overweight at fifteen percent body fat as a female.
Reta seems odd for food noise since I use sema or tirz for that and reta for cutting. In a peptide powered cut enzymes up to about three times the upper limit are not very diagnostic by themselves. Any symptoms besides the labs. Exercise can raise AST and ALT. I had a mildly high reading months ago blamed on training and other labs showed it was nothing. Fifteen percent body fat is quite low for a female. How was that measured.
I am not cutting or in a deficit. Using reta for food noise and binge control after the January cut. Bilirubin total twenty, potassium five point four, GGT forty six just over, ALT fifty seven, AST fifty three. Amylase and lipase high normal. High protein no fried foods more sugar on weekends. Fifteen percent body fat female. Fat intake around fifty three to sixty grams.
Those numbers sit at the top of normal or just over so not an emergency. When my own enzymes were mildly up the doctor said ignore it and recheck in three or six months. Gallstones are unlikely here they usually cause pain if moving or stuck and only affect enzymes dramatically then. Age health starting weight current weight other meds and prior tests would help. Many drugs raise enzymes. If levels were already off before reta or loss then MASLD could be likely and ultrasound or fibroscan useful. Normal results beforehand would make reta more suspect. Tirz and sema and un
You can do these things. One check lipase especially if over one hundred eighty. Two get an ultrasound on the gallbladder. Three if stones show up you will probably get prescribed UDCA or ursodiol to dissolve them. Significant weight loss with or without GLP ones can cause this so check anyway.
Only if you do not drink alcohol. TUDCA or any bile salts with alcohol can harm the liver.
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