Participants note that sema doses are being pushed higher than previously discussed, with speculation this is a response to tirz and reta competition. Some view it as a patent-extension tactic that could lead to new branded combos like cagrisema, while others question whether the market can support so many similar drugs long-term. Several users report positive personal switches to reta and expect rapid obsolescence of current options within a few years.
What this discussion establishesWhether increasing sema doses is mainly a cynical sales move or a logical patent strategy
Still openWhich of the many upcoming GLP-1 options will actually find lasting market space beyond tirz
Nothing here is advice.
Last I heard they planned to increase sema to 5mg, but these studies are pushing doses even higher. Wonder if livers and pancreas can take that. Probably the same thing will occur with tirz.
Sema seems to be falling behind, and they're trying hard to keep up.
Exactly. And increasing the dose means using more of it. Seems like a typical big pharma tactic to me.
I don't like defending pharma companies, but it doesn't add up to invest so much in increasing doses of a drug whose patent is about to expire. Maybe it could prolong the patent somehow.
It seems likely they will secure patents on cagrisema that include much larger sema amounts than the usual amounts, drawing from work like the ones mentioned. Raising the levels of ordinary sema alone feels unlikely because the digestive troubles already hit so many users hard. The intended spot for cagrisema remains unclear to me, though it might go up against tirzepatide for those who see no weight drop from it. Only a tiny share of users fall into that category. Before long the supply of glp compounds will probably overflow the space. Does room really exist for sema, tirz, reta, maz, survo, cagrisema, orforglipron plus whatever else arrives, when tirz already meets the needs of nearly everyone?
They always give it a new name when the dose changes. Good point.
I've mentioned this before. Within five years everything will be outdated by something five times better that addresses five additional issues these don't.
That's the reason reta stands out so much, it covers everything we've discovered so far. This field moves fast.
Absolutely. Tirz and even unapproved reta are hitting them hard, so they're scrambling to stay in the game. I tapered off sema over 90 days as I switched to reta. The digestion slowdown has really helped me, both with sema and now reta. I've been on reta for a month as of the 18th. Happy with how it's going. No bad side effects to report. Everything's great for me.
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