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Stacking Tirz & Reta: do you plan to stack long term?

24 replies14 peopleOct 24, 2026☆ Follow
Summary

Should I stack Tirzepatide and Retatrutide long-term or transition between them for ongoing weight loss?

People describe starting Tirz then adding Reta to chase glucagon effects after hitting a plateau, with some rotating the two or dropping one once near goal. Most keep Tirz as the base for appetite control and bring Reta in only when needed, while a few plan to switch fully. Cagri is mentioned as an alternative but often causes fatigue. Long-term stacking is viewed as temporary by most, with maintenance usually on a single agent.

What this discussion establishesWhere people disagree

Whether two GLP-1 agonists plus glucagon provide meaningful extra benefit or simply overlap without clear advantage.

Still open

How long any individual should continue a stack versus dropping one peptide entirely.

Nothing here is advice.

24 replies · 14 people
CopperSignal15archiveopening post15h

Been on Tirz for eighteen months after a year on sema and down eighty pounds with thirty still to go. Maxed out at fifteen milligrams of Tirz then added Reta ten weeks ago hoping to switch over because it felt like Tirz had stopped working. Only three pounds lost since starting the add-on. Right now at ten milligrams Tirz and four milligrams Reta, planning to move to seven point five and eight this week. Logging food is tough past a week because I hate it after thirty years of doing it. Hoping the extra Reta makes staying in a deficit easier without constant tracking, but now wondering how long the stack should last and whether dropping Tirz completely makes sense.

GreyLedger42archive15h

Currently on five milligrams Tirz with five milligrams Reta and one point five milligrams Cagri. Still get some noise but it stays manageable and I can hit calories and nutrients. Not in a deficit anymore since the focus is building muscle, yet the combination works well so far. Stacking Tirz and Reta for about eight weeks, four of those with Cagri added. Started at fifteen milligrams Tirz and lowered it each week while raising Reta, aiming for at least four milligrams of Reta to get the glucagon effects.

RustMarble79archive15h

Would rather add an amylin agonist like cagri or elora if the main goal is keeping hunger and food noise down once high-dose tirze or reta effects fade. Knowing calorie intake roughly is still important for holding a steady deficit, though after a while it should become second nature since most people eat the same combinations regularly.

SlowLedger99archive15h
↳ replying to @CopperSignal15 (opening post)

Tirz stays as the main compound for maintenance and I bring reta in only when needed. Reta took time to ramp up but once it did it handled the final twenty pounds easily.

CopperSignal15archive15h
↳ replying to @RustMarble79

Tried Cagri for eight weeks and it only left me exhausted with no other benefit. Track food about once a month now, though it still feels tedious because the meals are basically the same every day.

AmberCinder46archive13h

Still thirty pounds from goal and for now plan to run Tirz, adding Elo if needed, for maintenance and bring in some Reta only if a few more pounds need to come off. No telling what the next weight-loss option will be in a year.

BrightSparrow36archive13h

Yes, because right now both give extra health benefits beyond weight loss. When newer options appear I will probably try those as well.

SlowLedger99archive12h
↳ replying to @CopperSignal15

Cagri did the same to me. The fatigue was too strong so now it only gets used once in a while.

SlowLedger99archive9h
↳ replying to @GreyLedger42

Building muscle is the step most people skip and later regret. Good call.

GreyLedger42archive9h

Never been able to add much muscle before. Hoping this time it works so metabolism can rise.

LevelTimber12archive6h

At seven point five milligrams Tirz per week now. Instead of going up to ten, thinking of adding Reta instead to get the glucagon benefits sooner. Saw someone say four milligrams Reta is when glucagon starts, so stopping the Tirz increase and reaching four milligrams Reta might keep the stronger appetite control from Tirz while adding glucagon. Anyone tried this exact approach?

↳ replying to @LevelTimber12

The idea that four milligrams is required for Reta to work is not accurate. It starts working from the first dose. Begin at whatever level feels right and adjust based on goals.

PlainAlder11archive6h

Recently added two point five milligrams Tirz to a ten-milligram Reta dose. It seemed to restart progress after a long stall. Doubt the stack will continue once goal weight is reached. Maintenance will be on a Reta dose only.

↳ replying to @SlowLedger99

Try Semaglutide instead. It can also reduce food noise.

↳ replying to @PlainAlder11

You can try quitting Tirz, but many who do end up going back.

SlowLedger99archive6h
↳ replying to @LevelTimber12

That is basically the path taken here: Tirz first, then Reta added later instead of raising Tirz further. Logging how each week feels helps show what each compound is contributing.

PlainAlder11archive5h
↳ replying to @SteadySparrow75

No issues on my end. The other person might be different. It appears to be working; a pound came off even though weigh-in was not on the usual day. Food and alcohol choices are not perfect either.

↳ replying to @PlainAlder11

Doing regular weigh-ins will change things for the better.

Moved from full Tirz to full Reta across eight weeks starting in June, going from five milligrams Tirz down to four milligrams Reta. They cover the same area for me with only minor differences in how they feel. Slight preference remains for Tirz after trying each alone. Reta might have an edge while still losing. Several years worth of both on hand so alternating or stacking will happen eventually. Staying on Reta alone for the next year at least.

BlueHarbour15archive3h
↳ replying to @GreyLedger42

As someone new and interested in trying Reta, why combine it with Tirz when the two do similar things?

SlowLedger99archive3h
↳ replying to @QuietThistle70

Same approach for maintenance here. Tirz is the main one and Reta gets rotated in when extra help is needed. Reta worked better for the actual loss phase once it was built up.

RustMeadow90archive2h
↳ replying to @BlueHarbour15

From what has been read in various places, the reason is wanting the glucagon effect from Reta together with the stronger appetite and noise control that Tirz provides, which feels weaker on Reta alone.

GreyKettle68archive2h

Need to look into this more. From a biochemical view it is not clear what two compounds hitting the same receptors really achieve. Maybe partial agonism lets them complement instead of compete.

NorthWillow72archive1h
↳ replying to @GreyKettle68

Anecdotally Sema appears strongest on appetite. Since all three act on GLP-1, the stronger Sema effect seems tied to that receptor. Stacking Sema with Tirz or Reta happens. For Tirz plus Reta the combination adds glucagon on top of GLP-1 and GIP. These are distinct agonists, not duplicates, so the chart of relative strengths suggests stacking can help in some cases. Not everyone needs it though. Goal was reached on Tirz alone as a good responder. Others add an amylin agonist like Cagri or Elora instead.

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