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Switching from Mounjaro to Tirzepatide then Retatrutide

4 replies3 peopleOct 2, 2026☆ Follow
Summary

experiences switching from Mounjaro to compounded tirzepatide then to retatrutide and heart rate side effects

Users note that moving from Mounjaro to tirzepatide is mainly a formulation change at the same dose so side effects should stay familiar. Heart rate increases are discussed as a broader class effect that appears more at higher retatrutide doses. One participant expects retatrutide pricing to improve by the planned switch date.

What this discussion establishesStill open

actual side effect outcomes once the user reaches retatrutide

Nothing here is advice.

4 replies · 3 people
NorthCinder19archiveopening postOct 2

Has anyone switched from Mounjaro to tirzepatide and later to retatrutide? I'm wondering about the side effects. I'm currently on Mounjaro at 7.5 but costs are pushing me to tirzepatide because it's less expensive. I'll stay on that until around March next year and check my progress. If things slow I was thinking of moving on but I'm worried about heart rate increases during the change.

BlueAnchor59archiveOct 2

Mounjaro is already tirzepatide so switching at the same weekly dose is mostly just a product change. Side effects should follow what you already experience at 7.5 rather than a new titration. Heart rate discussion in studies is a class effect. Tirzepatide can raise resting heart rate a little and retatrutide trials noted it more at higher doses but that is something to watch later with retatrutide rather than during the Mounjaro to tirzepatide step.

NorthCinder19archiveOct 2

Thanks very much. I'm not expecting problems moving from the pen to the peptide version of tirzepatide. My main question is about retatrutide side effects but since those are noted at higher doses that does reassure me a bit.

SharpCinder28archiveOct 2
↳ replying to @NorthCinder19 (opening post)

Retatrutide will only be cheaper by then especially with GBs.

NorthCinder19archiveOct 2

That's good to know.

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