ForumDosing & Titration

Severe reaction after accidental vein hit with NAD+ shot

8 replies6 peopleApr 1, 2026☆ Follow
Summary

what happens if NAD+ meant for subQ gets injected into a vein instead

The original poster experienced sudden intense head pressure, vision changes, chest tightness, burning sensations and dizziness after a hip injection that entered a vein. Symptoms peaked quickly then faded within about 30 seconds without intervention. Others confirmed similar short-lived reactions when a vein or well-perfused area was hit, and stressed checking placement first.

What this discussion establishes

Nothing here is advice.

8 replies · 6 people
SteadyAlder49archiveopening postApr 1

I was doing my usual shots before leaving for work. After placing 50mg of NAD+ in the hip, blood came out when the needle was removed. I figured I must have hit a vessel there for the first time but paid it no mind. Roughly 15 seconds later a sudden wave hit: vision turned bright white, head pressure felt ready to burst, arms and chest went from tingling to burning, breathing grew difficult from the tightness, and dizziness nearly dropped me. I assumed a heart attack or allergic shock. With the phone in another room I grabbed the epi-pen from the drawer hoping it would give time to reach help. I had the cap off and was ready to use it when the head pressure eased and breathing got easier. I waited another 15 seconds or so until it passed.

WryCinder57archiveApr 1

Good to hear you came through it. That sounds frightening. I think starting low and going slow is safest. 50 mg of nad+ seems high; from what I have read these are short-chain amino acids that work best with gentle, gradual signals. Lower amounts should reduce the risk.

SteadyAlder49archiveApr 1
↳ replying to @WryCinder57

This was not the first time. I had already lowered the amount to 50 mg twice weekly. Earlier I had been using 500 mg per week. The real issue was not the amount but that the shot went straight into a vein instead of under the skin as planned.

CopperWillow19archiveApr 1

Could you share more on the exact spot, whether it was a regular syringe or pen device, and the needle length?

PatientFenwick39archiveApr 1

Always draw back on the plunger first to check for blood before pushing the dose in.

SteadyAlder49archiveApr 1
↳ replying to @CopperWillow19

Right hip, 31 g 5/16 inch insulin syringe. I used to check but got careless after doing seven or more shots daily for nearly a year.

AmberAnchor83archiveApr 1

Surprising that a 31 g insulin needle reached a vein since it does not go very deep. Glad it turned out fine. Might be worth checking for blood on future shots in that spot since veins can sit close in the subQ layer.

SteadyFenwick56archiveApr 1

A couple of times when doing NAD+ under the skin I have hit a vein or a very vascular muscle spot and got the same kind of rush. It was alarming at first but faded within a minute or two. Both times happened when I was in a hurry and did not pinch up a good fold of skin first. Ears ring, chest tightens, heart speeds up, limbs feel heavy. It is like a sudden chemical stress response that passes almost as fast as it starts.

SteadyAlder49archiveApr 2
↳ replying to @SteadyFenwick56

It helps to know someone else has been through the same thing.

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