ForumDosing & Titration

Last Pen Dose?

22 replies7 peopleApr 3, 2026☆ Follow
Summary

How do you confirm you get a full final dose from a nearly empty pen cartridge without underdosing or wasting product?

Users describe watching the pen's dial and stop point to see remaining units, then either switching cartridges or extracting the last liquid with an insulin syringe. Several tried inserting a syringe into the cartridge to measure or purge air, with mixed results including one case of the stopper tilting and leaking. Pens generally indicate shortfall either by refusing further dialing or by displaying leftover units, and cartridge markings are viewed as unreliable. Refilling cartridges is discussed but flagged as a sterility risk.

What this discussion establishesWhere people disagree

Whether off-center syringe insertion caused a stopper to tilt and leak, and whether refilling cartridges is acceptable despite sterility concerns

Still open

Whether every pen model will either display remaining units or prevent over-dialing when a cartridge runs low

Nothing here is advice.

22 replies · 7 people
PatientAlder89archiveopening postApr 3

As I near the end of my first cartridge and only a tiny amount remains visible, how can I tell whether I'm still getting the full dose? I've already discarded liquid a few times to remove air bubbles. I started with a low-strength 10 mg per ml cartridge. There should be roughly 2-3 mg left, yet it looks like almost nothing. I'm currently at 1.5 so the dose is short, but I don't want to miss any of it either.

SharpHarbour48archiveApr 3

I push an insulin needle into the cartridge and pull the remaining liquid into the syringe so I can measure exactly how much is left of the pen dose.

PatientAlder89archiveApr 3
↳ replying to @SharpHarbour48

Thanks, that's a good idea. Will the plunger still work afterward though? I prefer using my small pen needles.

PatientAlder89archiveApr 3
↳ replying to @SteadyQuill55

Right? My husband said just to toss the last bit so I wouldn't risk getting a short dose, but I figured someone here would have a better suggestion.

SharpHarbour48archiveApr 3
↳ replying to @PatientAlder89

You can push it back in, but that defeats the point. You can usually pull the last little bit out of the cartridge with the syringe anyway. There's always some left after the plunger stops moving.

SteadyQuill55archiveApr 3
↳ replying to @SharpHarbour48

This also looks like a reasonable way to test whether the pen is delivering accurate units. Just insert the syringe needle, dial, push, and check the volume. It's simpler than trying to attach a needle and push into another syringe.

SharpHarbour48archiveApr 4
↳ replying to @SteadyQuill55

It works for that too. It's also useful for getting rid of that last stubborn air bubble.

SteadyQuill55archiveApr 4
↳ replying to @SteadyQuill55

Update: won't be trying that again. The stopper moved up unevenly and some liquid leaked out the bottom. It's only a small loss since I only have a few days left on this cartridge anyway, but I would have been upset if it happened with a full cartridge of something longer-lasting.

SharpHarbour48archiveApr 4
↳ replying to @SteadyQuill55

I'm not sure how you managed to do that.

SteadyQuill55archiveApr 5
↳ replying to @SharpHarbour48

No idea. The only thing I can think of is that I didn't insert the syringe right in the center because I didn't want to damage the area where the pen needles go. That might have made the pressure slightly uneven when I pushed. Just a guess though.

SharpCompass19archiveApr 5
↳ replying to @PatientAlder89 (opening post)

You watch the number you dialed and where it stops. If you dialed 20 units and it stops at 8, you're short 8 units. Then if you want you can try drawing 8 units out with an insulin syringe, or just load a new cartridge and give yourself the missing 8 units from that one.

WarmCompass17archiveApr 5
↳ replying to @SteadyQuill55

Sorry if I misunderstood, but did you insert the insulin syringe into the cartridge and then, without pressing on the syringe plunger, dial the pen to see whether the clicks matched what the pen delivered? Rather than pushing anything into the cartridge while the pen plunger was still engaged. Being near the edge of the rubber shouldn't matter; I do that all the time.

SteadyQuill55archiveApr 5
↳ replying to @WarmCompass17

I worked the insulin syringe plunger back and forth a couple of times without taking the cap off to loosen it up a bit. Then I pushed it all the way in, dialed the pen twenty clicks, put the needle into the cartridge near the edge, and pressed the pen to inject. I got twenty units in the syringe, thought it worked, injected it, then picked the pen up and saw liquid around the bottom of the cartridge. The stopper was slightly tilted. I wiped inside the cartridge, put it back, attached a pen needle, and wasted a few units to check if the stopper would straighten, which it seemed to. I agree it shouldn't have happened, but it did.

WarmCompass17archiveApr 5
↳ replying to @SteadyQuill55

My stoppers are often slightly tilted; the plastic plunger can go off center easily. Maybe that particular stopper wasn't perfectly round and leaked on its own. These things are mass-produced and some probably shouldn't have passed quality control.

PatientAlder89archiveApr 16

For anyone wondering, I finally reached the end of the cartridge. Looking closely I saw the 20 line on the holder, so I thought a 15-unit dose would work. I was wrong. The pen stopped and showed 3 units still left. I had the new cartridge ready and finished the dose with that. I didn't know the pen would do this, but it's useful to know if you don't get the full dose.

SharpThistle74archiveApr 16
↳ replying to @PatientAlder89

Different pens act differently. Some won't let you dial past the remaining amount, others stop at whatever is left. Either way it's helpful and tells you how to finish with the next cartridge. The markings on the cartridge itself are not accurate.

BlueAlder28archiveApr 16
↳ replying to @SteadyQuill55

That's actually the method Peptide Critic recommends for checking pen accuracy, and it's how I found out my Amazon pen was inaccurate. I will admit I've done the opposite of what people here are doing: instead of pulling the last bit out, I used a spare reconstituted vial and a 3 ml syringe to push liquid back into the cartridge while it was still in the pen.

SharpThistle74archiveApr 16
↳ replying to @BlueAlder28

When the plunger is pushed down the cartridge is open to the air and no longer sterile. Refilling it and pushing the plunger back out is a reliable way to contaminate the cartridge. I would advise against doing that.

PatientAlder89archiveApr 17
↳ replying to @SharpThistle74

I didn't know until I finished my first cartridge. I'm glad it shows the shortfall so I don't have to worry about missing part of the dose. Not every pen may do this, so it's helpful, especially for someone new like me. I started this thread because I knew the cartridge was getting low and had no idea what would happen.

BlueAlder28archiveApr 17
↳ replying to @SharpThistle74

I get that. That's the reason I began my comment by confessing to having done so. I'm not suggesting anyone else try this. It happened as an immediate response after receiving just part of the amount when the device emptied. I recognize the potential danger involved. This danger seems smaller than the possible bacterial contamination in my substances prior to starting purification a few weeks ago. I'm fine with the choice.

SharpThistle74archiveApr 17
↳ replying to @BlueAlder28

I wanted to make sure everyone else understood the risk too. Filtering and avoiding refilling cartridges are the safer approaches.

WarmCompass17archiveApr 18
↳ replying to @BlueAlder28

To be precise, if you didn't push the cartridge stopper back far enough that the exposed area went back into the fluid chamber, it might still be okay. You can only do that once though. Instead I suggest pushing some air into the cartridge and pulling the remaining solution out with a syringe so you can use it. Part of me hates seeing the few units still stuck to the sides go to waste.

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