Users report personal or family use of SS-31 in type 2 diabetes with mixed context around metformin; some note improved HbA1c and kidney markers when combined with other compounds, while others flag theoretical mitochondrial conflicts and strongly prefer GLP-1 agonists like reta or tirz for glucose control. Animal data is cited as promising but human anecdotes remain limited and cautious. Lifestyle and standard medications are repeatedly ranked higher than peptides.
What this discussion establishesWhether SS-31 should be prioritized or avoided when metformin is already prescribed, and how it ranks against tirz/reta
Still openActual clinical interaction between metformin and SS-31, plus long-term human outcomes
Nothing here is advice.
Has anyone here given ss31 to a person with diabetes or know someone who has? My mother has type 2 and takes metformin; I have been considering whether to bring up ss31 with her. Some animal research looks positive though it is still early. Mainly hoping for firsthand accounts.
Diabetics probably already have impaired mitochondria so I would try it. I am starting ss31 on Monday myself.
Is she carrying extra weight? If yes, reta might bring her sugars down enough to drop the metformin. Nothing else I have tried comes close, plus it helps with weight.
I have type 2 and am using reta along with nad and kpv plus a second round of ss31. Two blood tests so far show my hba1c now below the diabetic range and my kidney numbers moved from stage 3b to 3a, which looks promising. I credit ss31 with part of that improvement.
Metformin and ss31 may oppose each other because metformin reduces mitochondrial activity. It is unclear if ss31 can overcome that or whether it would even be useful. I would look at tirz or reta first for glucose control regardless of weight, and also consider jardiance. Diet and exercise come before any of these. From what I have seen, ss31 would sit lower on the list.
I am on week three of ss31. The first two weeks I used only that, then added mots-c yesterday. So far ss31 feels very gentle with zero side effects, not even injection site reaction. Mots-c on the other hand always leaves a lump for a couple days.
Mainly because diabetes tends to damage mitochondria and ss31 supports them. I also read that mots-c might be especially helpful for women. That led me to look into ss31 and I found some encouraging animal results, which is why I wanted real-world feedback.
Yes she carries extra weight. She also gets tired very quickly so mitochondria support seemed worth trying first. Both my friend and I are currently on ss31 with no side effects at all.
Thanks for the update, that is helpful. She has started getting nad infusions and I can offer her some nad as well. She is already on klow and I would like to add ss31. Could you share the amounts and schedule you are using for each?
That interaction point is useful, thanks. My own reading suggested they act on separate pathways so they might be compatible, but I am not sure. She trusts her doctor completely and will not stop any prescription unless she feels clearly better. Her doctor would never recommend peptides, so it is a difficult spot.
Would any supplementary insurance or the provincial system cover mounjaro or tirz for her diabetes diagnosis?
That interaction detail is really interesting, thank you. I am also type 2 and currently combine reta, elora and triz with metformin. An ss31 kit is arriving soon but now I am rethinking how or whether to add it.
NAD tissue levels drop in sedentary older adults even when blood levels look normal, and they rise again with exercise. A recent human study also linked nad and nr supplements to worsening of early neurological conditions like parkinson’s. A glp-1 plus an exercise plan would be my first choice to protect muscle while losing weight.
Came across this note about a big study on NAD support that turned up no gains for Parkinson’s patients. The Norwegian Phase 3 NOPARK trial showed nicotinamide riboside left clinical results unchanged.
Type 2 diabetes affects me too and I finished one round with as-31. Rybelsius was my medication during 2024 plus 2025 yet weight stayed the same. Insurance reasons brought me back to metformin at the start of this year before switching over to Tirz by April. Several months passed on Tirz alone until my current stack includes Tirz along with Reta and Cagri. Recent lab results from three weeks prior plus today's checkup showed excellent kidney performance and an A1C reading of 5.4 so no prediabetes stage. Ss-31 caused zero troubles for me though nothing noticeable happened either. My other items include Mots-c, nad, aod9604, modified KLOW, CJC with ipa, Selank, Semax, kisspeptin, pt-141 plus 5amino
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