Tirz + Cag stack

I’d be cautious with Cagri, especially when it’s added to a solid dose of Tirz or Reta the way most people here seem to do it. At 0.5 mg I get mild nausea and at 0.75 mg it becomes unpleasant though still manageable, so my limit on top of Tirz 15 mg or Reta 5 mg is 0.5 mg weekly. Some here go up to 1–2 mg, but the majority stay around 0.5 mg. Side effects differ a lot between people, yet the pattern with Cagri on the forum is fairly consistent—most keep doses low when using it as an add-on. If 0.25 mg produces nothing and you’ve waited 48–72 hours for it to absorb, another 0.25 mg is probably low risk. That small bump is safer than jumping straight to 0.5 mg a week later. You can’t really judge from your Tirz tolerance because the receptors are different. Nausea and fatigue are the usual complaints, but they often stay mild at the lower doses people actually use.

My current schedule is Tirz 12 mg, Reta 4 mg, and Cagri 2 mg, all every six days and spaced two days apart. I didn’t add Cagri mainly for weight loss at first—I wanted it to quiet the constant food thoughts. I was losing only two or three pounds a month then. Later I added Reta once the Tirz-plus-Cagri combo slowed. Started Cagri at 0.5 mg every six days and stayed there two months with no sides but also no real change in the scale. Went to 1 mg, then three weeks later to 2 mg. In the three months since starting Cagri I’ve lost another 12 lb, but the last week has been flat even at the higher doses. On the bigger amounts I get some sides that seem mostly from the Tirz—tinnitus and allodynia—plus maybe a little mild stomach upset that could be the Cagri.

12 lb in three months sounds great to me. I lose slowly, so that would feel like a big win. How much total have you dropped so far?

Second week of Cagri on top of 12.5 mg Tirz. Appetite dropped after the first 0.25 mg dose, but the scale hasn’t really moved yet. I added it hoping to break a stall, though it’s probably still too early to judge. No bad reactions from the Cagri so far.

The reports are all over the place—plenty of people say Cagri smashed their stall, but just as many say it did almost nothing. Could be individual response or differences between sources. I’ve lost nearly 50 lb in six months and still have a ways to go, but I’m currently stalled. If Cagri doesn’t help I’ll probably push Tirz higher than 12.5 mg every six days; I’m not against going past 15 mg if that’s what it takes.

If a solid trial of Cagri doesn’t get you moving, Elora might be worth looking at. No one really knows yet how it performs if Cagri didn’t do much, but overall it seems stronger for weight loss. I’m on a similar stack—Tirz 15 mg, Reta 6 mg, Cagri 0.5 mg—and can’t raise any of them further, but it’s still helping control hunger enough to hold a 55 % loss. I added Reta instead of swapping because I liked the lack of sides on 15 mg Tirz and didn’t want to risk losing that, even though I was still a bit hungry. Sounds like you might be nearing the current limits of these meds for your body. If you have no Tirz sides, higher doses are still an option, or adding/swapping to Reta. Staying at BMI 30 is still way better long-term than BMI 40, even if it’s disappointing not to reach a normal range.