Retatrutide 8mg - increase dose or stay put?

I used tirzepatide rather than retatrutide but agree with staying on a weekly schedule. With only ten pounds left and two possible 2 mg steps available, raising the dose makes sense if side effects are not a problem. When sides do appear, the person mentioned earlier has had good results with various split approaches.

That is why I would move straight to 10 mg. No stall was mentioned.

Splitting is worth trying, and shortening the interval below seven days as well. A small adjustment should get progress moving again.

What makes you avoid splitting? I dropped nearly twenty-five kilograms by dividing 5 mg tirzepatide into 3 mg and 2 mg on Wednesday and Sunday. When progress stopped I slowly raised to 10 mg still split, but results were limited, which is why I switched to retatrutide and began splitting that as well. The difference in food noise is noticeable. It now seems likely that long-term use with very slow reductions will be necessary. Until recently I thought I could handle the noise through willpower alone.

Thanks for the honesty. The people I see who stop successfully put in a lot of consistent effort to hold the weight. For those who would rather focus energy elsewhere, staying on the medication is the simpler choice.

Because I never ran into those problems. Hunger never returned on day six and I had no side effects up to 10 mg. I am now on maintenance with 6 mg and 8 mg and plan to stay there as long as possible, possibly dropping to 2-4 mg later.

Switching to liraglutide would teach plenty of lessons about how difficult things can feel. For retatrutide or tirzepatide the useful adjustment is often splitting, for example every four days while keeping the weekly total the same. For maintenance some people do well every two weeks, which can be more practical when limited to single-use pens.

I appreciate the thought, but being told to improve discipline does not address the pattern. The increase in appetite happens at the same point each week as the medication effect declines. That is different from ordinary hunger that willpower should override. These drugs are meant to reduce appetite, so when the effect lessens the drive returns strongly. It is comparable to an allergy tablet that works most of the day and then wears off; no one would say more discipline is needed to stop sneezing. I have tracked this for two years and the timing is consistent. That is why I asked whether splitting, changing the dose, or another adjustment has worked for others who saw the same weekly drop-off.

I am considering adding some tirzepatide for my wife alongside the retatrutide. She does not seem to be losing anymore but refuses to weigh herself. She still wants her shots and is at 12 mg. I would need to discuss lowering the retatrutide dose with her. I have not looked into the details much yet.

Maybe eloralintide or even semaglutide? As her medical provider you could ask her to step on the scale even if she does not look at the number. Think she would agree?

Yes, I lift weights five days a week plus cardio or cycling. Bloodwork is normal; I have it checked every six months. I have considered tesamorelin or semorelin but want to read more first.

My wife uses both. She is at 12.5 mg tirzepatide and currently 6 mg retatrutide. She began with tirzepatide and was already at the top dose when we learned about retatrutide. As we raised the retatrutide we have started lowering the tirzepatide. I am also thinking about adding cagrilintide or eloralintide to improve appetite control.

Good luck with that. She finds the scale discouraging. I stopped arguing that it is simply a progress tool.

Nothing sharp anymore unless it is cold or irritated.