Of the big 3......

Tirz took off 22 kg in twelve weeks with zero sides and wiped out food noise completely. Skipping reta for now because of the heart-rate increase shown in studies and because it is still in phase-three trials, so it does not feel safe enough yet.

You can stack them all, lol.

Sema did not work nearly as well for me as tirz has.

Lots of different views out there. Plenty of people run low-dose cagri for the appetite piece and reta for the fat-burning side. Cagri did not sit well with me so I tried low-dose tirz plus reta instead. Even in maintenance I still want the suppression and I am looking forward to testing eloralintide at a low dose while staying on reta.

Reta is better at sparing muscle and fighting insulin resistance. Tirz is better at killing food noise. Sema is best at causing nausea.

I cannot see how reta would do anything for me. I am already at 15 mg of tirz and it is not doing much anymore. Used to get punished for overeating but that effect faded. No evidence any of these are magic; they are supposed to train you but I guess I am too stubborn for that.

Seen reports that sema scores highest on appetite suppression. RS did fine on it until it quit working, then added cagri because it works through amylin instead of GLP-1 and that made a noticeable difference. Switched RS to tirz at the start of the year and things are going well on that. Took me a while to figure out the best path forward.

Started at 336 late 2022, got down to 318 on my own, then lost 106 pounds on sema from mid-2023 to early 2025 before stalling around 211. Tried stacking 3 mg sema with cagri but it caused terrible constipation so I dropped the cagri. Lost over a third of my starting weight on sema alone, which is surgery-level results. Switched to tirz then reta at max doses separately but neither produced more loss. Went back to 1 mg sema for maintenance and slowly gained back to 224 by end of 2025. Now trying a sema-reta stack, currently at 218 aiming for 190. Running 1 mg sema on Mondays and 4 mg reta on Thursdays after four weeks at 2 mg. Need the hunger control that sema gives me because tirz and reta did not provide it on their own. Might add tesofensine later if this does not move things.

Cannot speak to reta or sema, but after only six weeks on tirz the change is huge. Fought weight my whole life and this is the first time in years I do not feel constant hunger and food noise. Results so far are unbelievable and I am already seeing clear physical changes.

Running reta at 4 mg every 84 hours. The final twelve hours or so hunger creeps back in. Suppression is definitely weaker than on tirz, but high-dose tirz was rough for me and left me wiped out for days. Hit a long plateau on tirz so switched to 8 mg reta over eight weeks. Scale has not moved much but I have lost noticeable fat around the middle, hips, and neck. Clothes fitting better matters more than the number anyway.

Been trying to lose for the past year. Weighed 429.5 in February 2025 at a doctor visit. Dieted and made small activity changes for twenty weeks and lost about twenty pounds. Not satisfied so looked into GLP-1 options and started reta in September at 2 mg, now up to 8 mg. Down to 357.7 yesterday, roughly fifty pounds in five months with little added exercise and loose calorie tracking. Focused on protein since appetite is low much of the time.

Used compounded sema before with some success but sides were bad enough to stop. Started reta recently and saw appetite drop right away at 0.5 mg, though it faded by day five or six. Titrated to 2 mg and suppression now lasts the full week, though some days it is hard to hit protein goals. Used to be a constant boredom and evening snacker; now the idea of snacking does not appeal. Stopped keeping those foods around to avoid temptation. Eating is now about hitting protein and fat targets rather than grazing. Might have seen similar results staying on sema but the sides were worse there.

Thought about food constantly and could not stop once I started something. On reta I have zero interest in food and struggle to even make dinner. Nothing sounds good. If something tasty is in front of me I might eat it but I do not keep those things around. Focused on protein. Also completely turned off alcohol, which I miss a little.

Super slow responder in general. Took eighteen months of diet and training to go from 190-195 down to 150 and have been stuck there a year. Switched from sema after it stalled to tirz and finished the loss. Tried reta but got diarrhea once I hit 4 mg even splitting doses. Now on 8 mg tirz weekly for maintenance because my body likes being around 150. More interested in building muscle than the scale number anyway. Stay on tirz because I was borderline prediabetic.

Would help to know how much overweight you still are, whether two hundred pounds or just another twenty. Age, how long you have carried the weight, and past attempts matter too. Medical checkup makes sense especially if older or with other conditions. Dose and sides from sema are relevant. If sema is still working and you are below 2.4 mg with no sides, just increase it. Otherwise switching to tirz or reta is reasonable; tirz usually has fewer sides while reta may be stronger if you have a lot left to lose. Cagri is best saved for when max doses of the others have stopped working, added low and slow because it tends to have more sides.

Moved from sema to tirz starting at the lowest dose. After six weeks now at 5 mg tirz with about a pound a week loss, which is fine since I am fifteen pounds from goal and twenty from stretch goal. Stacked 0.2 mg cagri with sema earlier but saw no extra movement. Always had gut issues so sides have not stopped me. From obese to healthy weight has been a long process and a big education. Where you start and where you are in the journey affects how fast you lose. Not everyone responds the same to each option. Medicine is not exact. Do your research, ask questions, and find what works for you.

Will not underestimate retatrutide. Hit goal on tirz then switched and appetite rose but weight kept dropping on the maintenance dose. It burns the fat regardless of hunger for me.

Eating a bit better but I think the GIP and glucagon activity in retatrutide is doing the work. Exercise habits have not changed much. Only wanted to go from 202 down to 170.

Moved from tirz to reta. Tirz has stronger appetite suppression but it came roaring back once I lowered the dose to start reta. Wanted reta for the more balanced profile and reported extra benefits like anti-inflammatory and heart-health effects. If it were me I would switch to reta and titrate slowly. Note that reta can take longer to build up if you have been on another GLP-1, sometimes four weeks to steady state. Everyone is different though.

Found reta really good at stopping food noise without completely shutting down the ability to eat, which may not be ideal anyway. Started at 2 mg weekly, moved to 4 mg, and now chatter is gone but I can still eat when needed. Cannot stuff myself or want junk food. Can eat clean food and hit macros to protect muscle. If you reach therapeutic dose, exercise, and eat clean it feels like the best option. After trying sema and tirz I am convinced reta is the healthiest choice, at least for me.