ForumDosing & Titration

Appetite increase tirz to reta switch

11 replies5 peopleOct 20, 2025☆ Follow
Summary

Why does switching from tirzepatide to retatrutide increase appetite and how can it be managed?

Users report that low-dose retatrutide added to tirzepatide often fails to control hunger and food noise as effectively as tirzepatide alone. Some experience stronger cravings, especially for sugar, which they link to retatrutide's glucagon activity. Raising the retatrutide dose, temporarily increasing tirzepatide, or adding a low dose of cagrilintide are mentioned as ways people have tried to restore appetite control while preserving muscle-sparing benefits.

What this discussion establishesWhere people disagree

Whether increased appetite on retatrutide is a drawback to fix or an advantage for muscle retention and avoiding overly aggressive deficits.

Still open

Optimal dosing strategy and long-term outcomes when combining or switching these peptides.

Nothing here is advice.

11 replies · 5 people
SlowKettle18archiveopening postOct 20, 2025

About three weeks ago I added Reta to my weekly weight loss pinning routine. I was really excited because of all the hype around it. Since I'm fairly new I got some to make sure it was the real thing. Week one I took 1 mg of reta along with my 10 mg of tirz. I've been on 10 mg of tirz for almost three months now. Week one I saw little to no change, so after some reading I tried 2 mg the next week. The scale has barely moved, maybe a pound that comes and goes, but my physique looks leaner. Appetite has been way up though. I know reta isn't strong on food noise, but has anyone actually felt hungrier than before starting it?

AmberMarble84archiveOct 20, 2025

Reta is a weak appetite suppressant for many people, especially at low doses. This is common when coming off tirz, which is much stronger at killing hunger and food noise. You need to increase the dose. You're only at 2 mg. I came from 10 mg tirz and I'm now on 5 mg tirz plus 5 mg reta, still adjusting the amounts. You could also add a low dose of cagri like 0.125 or 0.25 mg to help control appetite. You should look for better options than what you paid.

SteadyMeadow36archiveOct 20, 2025
↳ replying to @SlowKettle18 (opening post)

Just to clarify, on the second week did you take the 10 mg tirz together with the 2 mg reta or only the 2 mg reta?

SlowKettle18archiveOct 20, 2025
↳ replying to @AmberMarble84

I've heard about cagri recently since I'm still new to this. Have you tried it and how did it make you feel?

AmberMarble84archiveOct 21, 2025
↳ replying to @SlowKettle18

I have to admit the glucagon part of reta makes me crave sugar and feel very hungry. That could be the reason. You can go back up on tirz for a while until you raise the reta dose, or you could add cagri.

AmberMarble84archiveOct 21, 2025
↳ replying to @SlowKettle18

Yes, I started with sema with no luck, then tirz which worked but made me depressed at higher doses, then reta which made me super hungry and my sugar cravings went way up. I added 0.25 mg cagri four weeks ago and it really helps a lot. It's effective and I have no side effects. Fatigue and GI issues can happen with cagri though.

SlowKettle18archiveOct 21, 2025
↳ replying to @AmberMarble84

I'll have to look into cagri. I've seen it's a bit pricier than even retail now though so I'll keep an eye out. Thanks for the advice.

WryCinder45archiveOct 23, 2025

I actually view the stronger hunger signals on this compound as something helpful rather than a drawback. On the prior medication my desire to eat dropped so sharply that I ended up consuming far too little for weeks. That pushed my system into a protective state where it held onto weight even while I stayed in a deep energy shortfall. It therefore follows that this newer option leaves more room for normal eating since it supports keeping lean tissue through adequate protein intake while directing changes toward fat stores. Earlier versions of these medications fall short there and many users steer clear because of the chance of shedding strength-building tissue. That kind of tissue supports everyday movement and function so its loss shows up quickly in routine tasks.

SlowKettle18archiveOct 25, 2025
↳ replying to @WryCinder45

Never thought about it like this. I have a bad habit of watching the scale. My goal is to get to 200 pounds but I've been sitting around 220 with reta. I'm wondering if I should stop for a couple of months, do a higher dose of tirz while still lifting and hitting protein, drop to 200, then go back on reta and micro dose tirz so I don't go crazy with eating.

BlueWillow27archiveOct 25, 2025

If a physician is available to discuss the situation, that would be the route I'd take for sorting it out. In my own case the drop in hunger didn't show up until the five-milligram level, and even then the effect felt milder than what five milligrams of tirz delivered. Anything above five milligrams of tirz made meeting my protein targets impossible. Reta let me reach the equilibrium that suits me.

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