Several users report minimal appetite suppression even after raising doses over months, with some noting better results after adding vitamin D and magnesium while others see only inflammation relief or strong side effects without hunger control. Stacking additional compounds produced mixed outcomes, and one person experienced severe GI issues plus increased hunger throughout titration. Non-response is often linked by participants to possible insulin resistance or individual biology rather than dosing alone.
What this discussion establishesParticipants differ on whether vitamin D status explains non-response and on the value of adding further compounds versus accepting limited effects.
Still openThe underlying cause of low or non-response remains unclear, with suggestions ranging from vitamin levels to insulin resistance but no consensus.
Nothing here is advice.
Someone is not getting much appetite control from these peptides and wants to know if others have the same issue. They ask whether people simply raised the amount, what side effects showed up, whether anything else helped, and if anyone has thoughts on why it happens.
Medical comments have connected low vitamin D with weaker responses. After starting vitamin D and magnesium this person now feels they respond much better than before.
They were already planning to add vitamin D and asked what dose the other person had been using before that change.
Before the addition they were using 5 mg with only brief suppression. On the fourth week at 7.5 mg they struggle to eat more than 800 calories daily and have thought about lowering it or switching fully to another option. They add a small weekly amount of a second compound that gives little suppression and tried a third one that produced noticeable effects even on days it was not used.
They suggest pairing D3 with K2 for better uptake and adding magnesium as well. Taking it with a little fat, such as alongside fish oil, is also recommended to get full benefits.
They found it interesting how many processes involve vitamin D.
At 2.5 mg there was no appetite effect but clear reduction in inflammation. They feel they need to keep raising the dose for suppression and are now at 10 mg after the second injection, also thinking about small amounts of another compound.
They asked how 10 mg has been working. Their own current approach uses 10 mg of one compound, 10 mg of a second, and 1 mg of a third, yet they still eat normally with very few side effects.
Appetite control feels weaker now than it did at 5 mg or 7.5 mg, though eating habits have improved since starting in March. They want to try the new compound to see if it adds anything, noting that appetite effects are reportedly limited for many. They were surprised by the high combined doses being used.
At 5 mg weekly of one compound they can go longer without hunger compared with before, when they would want another large meal after three hours. Suppression became noticeable at 4 mg but was still modest. At the current dose fullness arrives quickly and mild nausea can occur while eating, though it ends once they stop. Food noise is lower but not gone, and they also avoid eating close to bedtime because of another protocol, which may help.
They began with one compound then added a second. They suggest trying a third if the goal is stronger suppression, but note it would not address glucagon activity if that is the reason for adding the second compound.
They asked whether metabolic effects still appear even without strong appetite changes. They recently began and have seen little suppression at 3 mg, hoping they will not require very large amounts to notice anything.
They wondered whether the idea of using small amounts of a different compound makes sense when appetite did not respond to standard doses of the first one, and whether the mechanisms differ.
The aim is better metabolic health along with diet and exercise. Eating habits have already improved and some suppression occurs, though less than for others. The new compound is wanted for its glucagon action to increase fat loss through thermogenesis, since building muscle seems to slow scale weight loss. Focus is on lean mass rather than total pounds, but slower loss is still noticeable.
They were glad the thread started because mentioning poor response to one compound often brings questions about source or self-control. They did raise the dose steadily over six months, increasing by 1 mg every four weeks and then jumping higher. Side effects were severe, mainly ongoing GI problems plus unusually strong hunger and constant thoughts about food. Nothing from this class has worked; one additional compound was tried briefly but proved too difficult. They suspect insulin resistance may be involved given family history, despite not being diabetic themselves.
They usually experience only mild side effects and wondered if low responders also get fewer side effects. Someone they share with feels strong effects at low amounts of one compound. Their own background includes successful natural dieting, yet without weighing food they now need higher doses to avoid overeating. They had not heard of the new option mentioned and eventually found a workable combination of several compounds that provides enough suppression, though it would likely cause heavy side effects for most people.
They also consider themselves a low responder but with a different timeline, having started directly with the newest compound after hearing about the class earlier. They titrated to 12 mg over sixteen weeks and felt stomach fullness plus constant acid reflux but no appetite reduction at all, only strong hunger. Reflux continued day and night. Lowering the dose and adding a small amount of another compound for two months produced no appetite benefit. They have now been on a different compound for two months, lost nine pounds, and report no reflux along with good sleep.
If you have tried it, this topic is still open. Sign in to reply — it takes a minute.