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GLP-1s and Endurance Training: Better Power-to-Weight or Compromised Performance?

8 replies5 peopleOct 29, 2026☆ Follow
Summary

Do GLP-1 drugs help or hurt endurance performance through changes in power-to-weight, fueling, heart rate and recovery?

Users report mixed outcomes. Some see better consistency and Strava times from steadier eating and lower weight, while others experience sharp rises in resting and exercise heart rate that turn zone 2 work into zone 4 efforts. Tirzepatide appears better tolerated than retatrutide for heart-rate effects; performance impact seems driven more by whether athletes keep calories and carbs high around sessions than by the drug itself.

What this discussion establishesWhere people disagree

Whether the drugs themselves impair performance or whether under-fueling is the sole limiter

Still open

Long-term effects on VO2max, muscle retention and race-day power at higher doses

Nothing here is advice.

8 replies · 5 people
SlowAlder33archiveopening postOct 29

The title pretty much covers it. This is connected to another thread but looks at things from a slightly different angle. I've spent time thinking about how these medications interact with endurance sports and training. For me that means soccer, cycling, running and triathlon, though any endurance activity is relevant. Most discussion centers on weight loss, but for endurance work the real question is whether muscle, power and aerobic fitness stay high enough for actual gains. In cycling, for example, climbing improvement depends more on power-to-weight, endurance and recovery than on the number on the scale. One side of the trade-off is that lower weight can raise relative power on hills and improve running economy by cutting excess fat.

GreyAlder96archiveOct 29
↳ replying to @SlowAlder33 (opening post)

Mainly a mountain biker without a power meter, so no watts or VO2max numbers. Still, I've been topping or placing near the top on local Strava segments. I'm riding faster than ever. TRT is probably helping, and I also developed asthma from Army exposures, but the bigger change seems to be steadier eating instead of the old binge-and-diet pattern. Power numbers have gone up across different weights I've carried over the years, and I credit the removal of those big swings in intake. I've never reached a point where the medication stopped me from hitting my calorie floor, even at 2.5 mg sema or 8 mg reta per week. Two sandwiches before a ride still feel like rocket fuel, and that's basically the only adjustment I make on big days besides drinks and electrolytes. Perceived effort feels lower overall, which again traces back to steadier nutrition.

SlowAlder33archiveOct 30

Hard to argue against better Strava times, though the contribution from TRT is debatable. Fueling consistency clearly matters. It's notable that you've stayed able to meet calorie targets even on these doses. I've run into problems at lower doses, so maybe adding something else could reduce that risk, though I haven't tried it yet. Thanks for sharing the details.

PlainAnchor67archiveOct 30

Retatrutide pushed my heart rate way higher. What used to be zone 2 suddenly felt like zone 4. Appetite stayed normal on both retatrutide and tirzepatide, so getting carbs in was never an issue. After switching to tirzepatide my heart rate moved back toward the old baseline and I've been able to raise power and extend ride length again. From what I've seen, retatrutide is not something I'd suggest for endurance athletes or anyone else. It left me in rough shape.

BlueAnchor59archiveOct 30

I'm more into lifting than endurance, but the pattern here lines up with standard sports-nutrition guidance: the real constraint is usually under-fueling, not the medication. The practical fix is to place carbs around important sessions instead of relying on hunger. Easy intake beforehand plus 30-60 g per hour on anything longer than 90 minutes works, and drinks or gels go down better even when appetite is low. Keep protein high across the day to protect muscle, and try to schedule the hardest work away from the first couple of days after the shot when suppression peaks.

SlowAlder33archiveOct 30
↳ replying to @PlainAnchor67

I notice a small heart-rate bump even at 1.5 mg. If the effect scales with dose, I can picture how it would feel at higher amounts. What dose were you using? Glad tirzepatide has worked out better for you. Something worth remembering.

PlainAnchor67archiveOct 30
↳ replying to @SlowAlder33

I reached 7.5 mg per week. There were full days when resting heart rate sat above 100 bpm. I stopped completely, waited for it to clear, then restarted at 2 mg. Heart rate stayed elevated and sides remained bad. Last night was the first ride in months where average heart rate stayed under 140 bpm.

SlowAlder33archiveOct 31
↳ replying to @PlainAnchor67

That sounds concerning. Good that you've sorted it out. I've seen 76 bpm instead of the usual mid-60s and even that small change hasn't felt great.

WryFenwick91archiveOct 31

I posted about this recently and was really struggling. The main thing seems to be getting more carbs in. Over the past week I've added more potatoes because they're nutrient dense and high volume for the calories when you don't fry them or add lots of butter. I'm on a low dose of tirzepatide, just starting, which may explain why resting heart rate hasn't moved. I've heard the heart-rate issue is more common with retatrutide, which is disappointing since I'm curious about it. I have a power meter and will track that more closely than usual.

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