When should i up dose of reta?

One week is pretty short to judge your response. Trials began at 2 mg though, so if sides are tolerable or absent you could go up. Keep in mind it takes four weeks to reach steady state at the new level, so stay there a month once you move. I did 1 mg twice weekly for the first two weeks before going to 2 mg once a week, but looking back I probably could have started at 2 mg.

It takes about four weeks to reach steady state for any given dose. Steady state differs from therapeutic exposure. I switched from tirzepatide to reta specifically for the glucagon signaling and aimed for roughly 6-8 mg weekly to activate that pathway reliably. Because I was already on a GLP I ramped faster with small frequent doses while monitoring sides and reached an accumulated 7.5 mg level by day 16 with no major problems.

It comes down to how you tolerate it. I began at 2 mg and raised by 0.5 mg every five days. I'm about to pin 4 mg next, maybe 4.5 mg, because sides have stayed mild and I'm still eating normally except for less snacking and overeating.

I would have no problem going straight to 2 mg and holding there for a few weeks to check tolerance.

I have no sides at 4 mg every 84 hours. If 1 mg per week is working I'd stay there the full four weeks before considering an increase. Titration next week is probably fine since 2 mg is the phase-three starting dose and you've handled it well so far. This is a long process though, and the medication builds gradually in the body.

It depends on your starting point and goals. If you are very overweight it can make sense to go slower because rapid loss raises risks like gallstones or fainting. Increasing faster than every four weeks raises the chance of strong side effects, and because of the long half-life those effects can linger a week or longer. Common sides include nausea, vomiting, diarrhea and constipation, and vomiting for days can become serious. Peak sides often show up around month two to four while doses are still rising. You really need to understand how the drug behaves in the body before speeding up titration.

What if you are using pre-filled pens? I've heard the potency drops once the solution is already mixed, so some people start higher. Does mixing your own with bac water mean you should begin lower?