Came across the latest retatrutide trial numbers and noticed they mention an abnormal sense of touch called dysesthesia. The way they describe it lines up with what a lot of us already call allodynia. The analysts expected the safety profile from phase 2 but this new signal showed up in the bigger TRIUMPH-4 study.
Dysesthesia in Retatrutide Trials: Is It Allodynia and How Do People Handle It?
Summary
What this discussion establishesIs the dysesthesia reported in retatrutide trials the same as the allodynia people experience on these meds, and does anything help?
- Users equate trial dysesthesia with the allodynia they already know from retatrutide.
- Symptoms often begin or worsen at 6-8 mg weekly and can persist for weeks or months.
- One person reported relief after adding palmitoylethanolamide.
- Splitting the weekly dose into smaller, more frequent injections reduced intensity for at least one user.
- Heat can trigger hot pins-and-needles sensations that restrict exercise and daily activity.
- A minority saw the effect appear or disappear abruptly with no dose change.
Whether the side effect was truly absent in phase 2 or simply under-reported, and how long it typically lasts once it starts.
Nothing here is advice.
9 replies · 8 people
Got myself some palmitoylethanolamide and oddly enough it appears to be helping. The feeling dropped quite a bit in the spot that's been an issue for months.
The fact that they didn't find this reaction important enough during phase 2 trials to include it really took me by surprise. People in this group experience it quite a bit.
↳ replying to @QuietWillow76
It seems that way from what you're saying, yet I figure they must be aware of this issue already. Man, that's unfortunate. Dealing with it over such a period. Explains why folks quit whatever they think might be triggering it.
↳ replying to @BrightKettle28
The trouble really kicked in once I reached eight milligrams of reta, and it kept up for roughly two months. Adding PEA though brought everything back to feeling regular again.
For around two or three weeks I dealt with allodynia. The amount stayed the same but the source switched. It started pretty quickly and stopped rather suddenly.
Coming across this thread has been helpful. What kinds of experiences do other people have with similar issues? Whenever I warm up, there's this prickly burning feeling that hits. It bothers me a lot, leaving me worried about ending up somewhere too heated and stopping me from physical activity. I never connected it to the medication before. Previously, without using it, the same thing occurred but much milder and disappeared by itself. This is annoying. I might switch back to the earlier choice.
↳ replying to @IronWillow10
I'm grateful and plan to attempt it right away. Skin sensitivity stands out as the lone problem with this compound. Its severity keeps me from going past five or six milligrams per week. The trouble began once I first hit that level so I break doses into two milligrams on alternating days. Occurrences continue though they seem milder after dividing the total.
↳ replying to @BrightThistle58
I get a buzzing feeling with tiny throbs that begin at the foot and travel upward along the lower leg. This shows up in just one limb. No ache comes with it, only an odd sensation. It shows up at the 1.8 milligrams per week level and stays the same ever since I began the medication. I plan to recall that idea about the additive if it comes up again later.
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