Eli Lilly’s new medication for alcoholism?

There’s some data showing GLP-1 drugs influence dopamine pathways, similar to how they quiet food noise, and that effect seems to extend to alcohol cravings. The exact mechanism for alcohol use disorder isn’t clear to me but I recall reading about it. Current options like tirzepatide might help with alcohol issues too.

Not sure about alcoholism specifically, but once I began reta my urge to drink disappeared. It felt strange; I can look at nice IPAs in the fridge and feel zero pull toward them.

Sema cut my alcohol cravings a lot at the start and let me stay sober for a stretch, roughly a 90 percent drop from before. Later some tough events weakened that effect. I still drink less overall, maybe half my old amount, and almost daily again. I started it for metabolic reasons but the real motivation was heading toward a dangerous level of liquor use. If you find the name of that specific one I’d like to know too.

It showed up as one of the top search hits. Maybe Brenipatide?

Lilly is studying Brenipatide for alcohol use disorder with a phase 3 trial underway, though results aren’t out yet. I was surprised they’re developing a separate drug when all the GLP-1s seem to show this effect, but maybe they want to avoid mixing signals with tirzepatide. It isn’t proven enough for routine recommendation yet, but lots of early data and study reanalyses point to lower alcohol and drug use, fewer hospital visits, and fewer overdoses. If the current trials confirm it, this class could become the strongest treatment available for alcoholism and possibly other substance issues too. No clear science yet on which agent is best, but both tirzepatide and semaglutide show the effect in studies and in many user reports here.

Are you thinking of Brenipatide? It’s also being tested for asthma I believe.

Tirz wiped out my urge to drink. I’m closing in on three years sober now. These meds worked better for me than naltrexone.

On reta I only feel like drinking if a certain flavor sounds good or I’m on vacation during social hours. Even then the amount is much lower because I get buzzed faster. It used to be hard with my husband being into craft beer and my own stash in the garage fridge. Now if I feel off I just sleep or do something else instead.

I saw some guy on TV promoting something with three letters, looked like a compounding clinic ad. Also used to enjoy martinis but tirz took that away along with seventy pounds, so no complaints here.

I used to look forward to getting hammered every Saturday and would sneak extra hard liquor. Started reta in June and now have zero interest. Haven’t been drunk since July. We’ll open wine and sometimes I don’t even finish the first glass before dumping it out.

Brenipatide is being studied for tobacco use disorder, asthma, obesity, alcoholism, bipolar, schizophrenia, depression, cardiovascular issues, liver problems, metabolic conditions, osteoarthritis pain, and more, with a once-monthly dose.

Reta ended my twenty-five-year weed habit after the first shot and knocked out my TCG gambling habit at the same time.

Finally something I’ll put on the do-not-try list.

Dang.

The phase-3 Brenipatide study is still recruiting according to the trials registry. It’s listed as a study in participants with moderate-to-severe alcohol use disorder.

I’m looking forward to that. Tirz hasn’t touched my daily ecig use though. Nicotine is still a big weakness and one day I’ll be ready to quit it for good.

Is this going to appear in the gray market?