Reta Beginner- Titration Questions

Most people here reach 2 mg within a month of starting. Some respond well enough to stay at 1 mg longer while others begin at 2 mg or move up quickly. Rotating injection sites is generally recommended.

You cannot really plan doses that far ahead because you do not yet know how your body will react. You just took the first shot so there has been no time to see effects or sides. The approach I use is to wait until right before the next dose to judge whether to lower it for sides, then after the fourth dose at any level decide whether to stay or increase based on results. I plan to reach the doses used in studies eventually but want to get there slowly.

At minimum record date, dose, weight and side effects. I began with the published protocol and developed allodynia and cramps while increasing, so I reduced the dose until the pain stopped but then weight loss halted. Switching to Monday and Thursday dosing let me titrate again until effects returned, though allodynia returned too. Moving to Monday Wednesday Friday at 2-2-3 mg worked for a couple months. Now at 3-3-4 mg totaling 10 mg weekly and losing about a pound per week again. Appetite control remains difficult. At 5 foot 10 and 210 pounds I imagine smaller people closer to goal weight need less.

I agree you should not plan that far ahead since response and sides are unpredictable. Curious where you saw that there is no need to go above 2 mg per week, because that level does not seem therapeutic to me. If 2 mg works there is no reason to go higher, but planning to stop at or below it does not make much sense.

Started low at 0.5 mg every three days because I had never used anything before and had no idea what I was doing. Now on 1 mg every three days with no stall in weight loss. Height 5 foot 9, 44 male, started at 216 now 187. Follow the clock around the belly button for injections. The Shotsy app is useful for logging dose, site, pain, notes and weight plus setting reminders and viewing trend graphs.

Regarding planning doses, go ahead and make contingency tables and publish results if that is your style. There are many options when running a trial of one. Even with tirz the standard schedules can feel too conservative. Microdosers believe therapeutic levels are lower than most assume. Different trials for reta used different schedules.

If a dose works stay there, otherwise move up after four weeks on the same dose.

I looked at Shotsy. It looks nice but only tracks glps. Need an app that tracks them all.

There is no need to dose more than once a week if side effects can be tolerated. The drug was designed for weekly dosing and should have better efficacy that way. Plan to remain at the same dose for at least four weeks to reach steady state.

By the way one known user favors higher experimental dosing rather than microdosing. Now that short-term orfo is available in the grey market it may help with daily dosing or boosts based on feel.