Participants suggest beginning at 2 mg weekly for several weeks before any increase, noting that prior tirzepatide use may allow slightly faster titration for some. One person reported moving directly from 15 mg tirz to 8 mg reta without issue, while another described a friend tolerating 3 mg reta after high-dose tirz. Several emphasize that tirzepatide provides stronger appetite control than reta.
What this discussion establisheswhether a 4-week titration interval is necessary for someone already exposed to tirzepatide or if 2-week steps are acceptable
Still openhow individual tolerance and heart-rate response to the glucagon component will affect final dosing
Nothing here is advice.
i searched the forum and reddit but came up empty. my brothers dad used to take mounjaro at 12.5 mg until the cost became too much. he had solid weight loss on it but has been struggling since stopping. he wants to try the reta that i'm on. what starting amount makes sense for him?
i came across this chart but don't know how reliable it is. i still wouldn't put someone straight onto a high dose without working up.
was he still taking it or already stopped? how long since the last shot?
have him begin at 2 mg of reta and stay there for four weeks. three weeks off should be sufficient for the previous drug to clear.
yeah that lines up with what i was thinking.
same view here. start him at 2 mg and wait at least three weeks before going up. make sure he knows tirzepatide usually suppresses appetite more effectively than reta does.
search for the word bridge plus my username to see how i moved from 5 mg zepbound over to reta back in january. i wouldn't drop straight from 12.5 mg down to 2 mg, though goals and tolerance differ for everyone.
a friend of mine came off 15 mg tirzepatide after more than a year when insurance ended. he started reta at 3 mg weekly after roughly two months off. when he later added tirzepatide back alongside the reta he began at 6 mg and tolerated it fine, then moved to 9 mg the next week.
because he already has exposure to tirzepatide the glp-1 and gip effects are familiar, so hunger is the main issue returning. the new glucagon part will raise heart rate and there's no avoiding that. when i switched i went straight from 15 mg tirz to 8 mg reta with no problems. starting at 2 mg and adding 1 mg every two weeks to check hunger control should work fine. four-week steps seem unnecessary once someone has prior exposure.
i've been in maintenance since may 2025. after a full year on tirzepatide i reached 15 mg for five months. i tapered to 10 mg, added a small amount of cagri, then stopped tirzepatide and began 1 mg reta with cagri. two weeks later i moved to 3 mg reta and later dropped the cagri. weight has stayed stable at 3 mg reta once a week and i can eat normally again.
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