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Have you experienced the reta face?

13 replies9 peopleApr 20, 2026☆ Follow
Summary

Does retatrutide cause a distinct 'reta face' similar to ozempic face, and does creatine impact the liver when taken together?

Participants largely attribute facial changes to the speed and amount of weight loss rather than the medication itself, noting that rapid fat reduction leads to wrinkles and sagging especially in older users. Many report looking better overall despite minor aging signs, and view ozempic-face concerns as overstated. Creatine shows no liver interaction with reta in personal bloodwork, and any water retention is muscle-specific rather than facial bloat.

What this discussion establishesWhere people disagree

Whether muscle loss in the face plays a meaningful role versus pure fat reduction

Still open

How skin will fully settle after major loss and whether long-term users see ongoing changes

Nothing here is advice.

13 replies · 9 people
BlueHarbour19archiveopening postApr 20

Do you think reta produces a face change like the one everyone online blames on ozempic, where 70 to 95 percent of users end up with that tired look nobody wants? Is there anything real to it? Also a quick side question about creatine monohydrate, since I heard stacking it with reta puts heavy stress on the liver because both are processed there.

CopperAlder25archiveApr 20

Ozempic face comes from staying in a big deficit that strips muscle, including from the face. On reta my face looks more defined and improved overall, though I have picked up a couple extra wrinkles that Botox can fix. I plan to add KLOW later to help appearance further. Creatine has never shown liver effects for me; years of use plus bloodwork on 5 grams daily with 2.5 mg reta left pancreas, kidney, and liver numbers normal.

SharpLedger58archiveApr 20

Most of the look comes down to how fast the weight comes off. The same facial shift would happen from identical loss achieved any other way. Unless skin is young and elastic, dropping a lot of facial fat creates wrinkles the same as anywhere else. I lost 50 lbs on keto over a year and got deep facial wrinkles plus sunken cheeks in my 50s. Switching to Tirz for more loss hasn't changed the face much beyond that.

SteadyQuill55archiveApr 20

Down 55 lbs at age 45 I look a bit older, with slight upper-lid sag and more obvious under-eye bags that run in my family anyway. I still look far better than when I was heavier, so it does not bother me. Losing that much in under a year means skin has not finished adjusting yet. Ozempic-face talk feels overdone and mostly comes from the idea that weight loss must come with some penalty.

PatientFenwick91archiveApr 20

I am too old and offline to fully grasp what reta face means. I see younger people posting sharper jawlines, but maybe it also refers to a tired, deflated appearance. Since I was already older when I started reta I cannot tell if any sag is from the drug or just normal aging.

GreenMeadow54archiveApr 20
↳ replying to @SharpLedger58

That is the right take. Results depend on age and how much weight is lost; younger users or smaller losses fare better. Face muscle loss might play a tiny role but is not the main driver. Reta actually improves fatty liver in studies, and creatine has been tested at high doses with no negative findings.

BlueHarbour19archiveApr 20
↳ replying to @CopperAlder25

That makes sense, so a slower cut would better protect face muscle while an aggressive one risks losing it and ending up looking worse. I have to admit I have probably done it wrong my whole life by using fast cuts for quick visible face changes and a big glow-up, never realizing it could cost facial muscle.

BlueHarbour19archiveApr 20
↳ replying to @GreenMeadow54

What about the face-bloating phase people report on creatine? I used to take 8 g daily at 80 kg but stopped after five weeks on 2 mg reta because of that side effect. I train four to six days a week plus run 30 to 50 km weekly, so should I restart creatine and, if yes, begin with a loading phase after the three-month break?

NorthSignal48archiveApr 20
↳ replying to @GreenMeadow54

I share that view. A connection between two things doesn't mean one is causing the other.

GreenMeadow54archiveApr 20

Creatine holds water inside the muscles, not as general bloat. It has nothing to do with reta. Loading is just marketing; a normal dose saturates muscles in one or two weeks anyway. Loading gets you there faster but offers no real advantage for something taken long term.

SharpLedger58archiveApr 20
↳ replying to @GreenMeadow54

I agree, no connection to reta. I take 10 mg creatine daily on good sleep nights, 15 mg when sleep is off, and 20 mg when sleep is poor. It stops my brain from dozing off at work.

SteadyTimber49archiveApr 20

At 45 and down 65 lbs in six months I have new facial wrinkles. My neck now shows my age more clearly since the fuller face used to soften it. I do not look worse than 45, just my actual age now.

GreenMeadow54archiveApr 20

Letting my facial hair grow made a noticeable difference. Folks often compare it to how a push-up bra works for the chest, except on your face.

RustLantern77archiveApr 20
↳ replying to @BlueHarbour19 (opening post)

As we get older we lose muscle, bone, and fat in parts of the face while gaining fat in others. Fast weight loss speeds up that aged look. It comes down to priorities: a slimmer body and face or keeping more fullness everywhere. I chose health and can always see an injector for HA filler later if needed.

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