To move or NOT to move?

Holding at 5 mg sounds reasonable to me. What was your starting weight and what are you aiming for?

Seven months on Tirz has taught me to remain on whatever amount is still working for as long as possible. For me that currently means 10 mg every fifth day instead of every seventh. I would keep the 5 mg going until hunger or food noise starts to show up again. At that point you could try a smaller jump than 7.5 mg, or test every fifth or sixth day. There are quite a few ways to adjust.

I only stepped up after appetite suppression faded or the scale stopped moving. Listening to your own body is the better guide for when to increase. Ignore the trial dosing schedules if you do not need to spend extra money.

I am six foot two, began at 386 pounds, and sit at 351 pounds after fifty-three days on Tirz. My target is 220 pounds.

The aim is steady, safe weight loss. I would keep the present dose until it fails to produce any change for a full month. Only then consider going higher. Using the smallest amount that still works for the longest time keeps both cost and side effects lower. Trial data showed little extra benefit from jumping to the highest dose right away versus moving up only when progress stops.

You are already seeing strong results on a low dose. Remain there until that changes. Return of food noise or several weeks with no movement on the scale are the signals to increase. There may come a time when even the top dose only maintains weight, so the longer you can delay reaching that point the better. These medications tend to produce their biggest drops early and then slow as the body adapts. Leaving room to move up later takes advantage of that pattern.

I have been on Tirz more than eight months and only increase when food noise returns and I notice myself snacking again. I split my doses and raise the amount by 1 mg per week when needed, which means 0.5 mg added to each half-dose. I usually stay on a given level for six to eight weeks. The hope is that this keeps my eventual maintenance amount lower. I still have ten to fifteen pounds left and time to adjust. Stacking another compound is something I would consider if a stall happens at higher levels.

Many others have already said the same, but my own experience lines up. Remain on a dose that is still producing results. Only move higher when food noise returns or you need to break a plateau that has lasted four to eight weeks.

I can only agree with what has already been said. Keep the current dose while it continues to work. If the final days before the next injection become difficult, splitting the dose is one way to handle it.

This diagram showed up during an earlier discussion.

I am still using the vial I opened on May 7th, so it is nearing the sixty-day mark. The liquid remains clear and I have had no side effects or return of food noise. I chose to take a modest step up to 6.25 mg to offset any slight drop in strength and to keep hunger away during the holiday weekend with lots of food around. That is 32 units instead of the 25 units I used for 5 mg. Once this vial is finished in the next couple of weeks I plan to return to 5 mg, expecting the fresh vial to feel stronger. Thanks for the input.