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So queasy and struggling to eat now

12 replies7 peopleSep 23, 2026☆ Follow
Summary

how to adjust dose after small increase causes nausea and trouble eating enough on retatrutide

A user increased from 3 mg to 3.4 mg split twice weekly and saw faster weight loss but then persistent nausea and early fullness that made hitting protein goals difficult. Some advised staying put since sides often fade, while others suggested waiting longer before any change or dropping back slightly. Experiences shared included varying effective doses across family members and differing views on titration speed.

What this discussion establishesWhere people disagree

whether to follow slow micro-increases or larger 1-2 mg steps every four weeks

Still open

whether dropping only 0.2 mg will restore appetite or if skipping a dose is better

Nothing here is advice.

12 replies · 7 people
PlainMarble21archiveopening postSep 23

I went from 3 mg up to 3.4 mg on 8/28 split as 1.7 mg twice a week. Felt okay at first and the scale started moving at about a pound a week instead of almost nothing. After the shot on 9/12 loss picked up even more, then after the 9/16 dose I started feeling full fast and queasy most of the time. Getting enough protein has been tough. I still took the usual 1.7 on 9/19. I've dropped another two pounds since the 17th so the rate isn't crazy but I wonder if I should lower the dose to eat properly or just stay here and wait it out. Today would be my normal shot day. Surprised that 3.4 feels so different when 3 wasn't doing much. Odd that the nausea built over a couple weeks. Would cutting just 0.2 mg to 3.2 actually let me eat again? Or skip today and restart at 1.6 on Saturday?

AmberPebble75archiveSep 23

I remained in my current spot and things eased up after a while. The discomfort never felt all that intense.

SteadySparrow75archiveSep 23
↳ replying to @AmberPebble75

Yeah, that matches what happened for me. In the beginning seven days using the smaller amount, I ended up vomiting. Still, by the middle of the week everything felt way better. Other than a few random times with stronger reactions after going up in amount, it has gone pretty well without issues.

PlainAlder11archiveSep 24

Those unusual decimals such as 3.4 and 3.2 with the reduction of point two milligrams don't make sense to me. Might this relate to a formula used in reconstitution?

PlainMarble21archiveSep 24
↳ replying to @PlainAlder11

My injection device lets me set exact increments without any guesswork. During August my level sat at three units for a 1.5 milligram amount split into two weekly shots. Late that month I raised it to 1.7 milligrams per shot, yet side effects appeared right after the one I took in mid September. The earlier amount never helped me drop weight, while this new level leaves me unable to finish normal meals. Now I need to decide what comes next, maybe stepping back or holding steady for a while.

PlainAlder11archiveSep 24
↳ replying to @PlainMarble21

Actually I would raise the amount by an entire milligram each step. Our adjustments came in two-milligram steps all the way to ten, while my spouse takes twelve. The exact trouble lasted for me right until six, where I barely ate anything yet still got my protein. Reaching ten let me meet my target and I could eat normally again, just smaller portions overall. My stomach capacity must have reduced. Precise dosing works fine on the half and third milliliter syringes, though bigger amounts call for the full one milliliter size. Did you mix yours with water, and what amount of bacteriostatic solution went in? What volume are the vials you are using?

PlainMarble21archiveSep 24
↳ replying to @PlainAlder11

I've been combining a milliliter of sterile water with ten milligrams of the substance. My current vials hold thirty milligrams apiece since four of us inject together. Over the past seven days I've struggled to consume enough protein. I just don't see why bumping the dose up by one milligram would change anything.

PlainMarble21archiveSep 24

To compare how the amounts vary in effectiveness, my spouse worked his way up gradually reaching three milligrams and dropped twenty seven pounds from early May onward. My child stayed steady at point eight milligrams while dropping forty one pounds. My mother began one month later than the rest of us and recently increased to two milligrams with a weekly drop of one pound. I take the most at three point four milligrams raising it by four to six tenths each month but my weight reduction has been the least among us. Since I am going through perimenopause my physician believes that plays a role.

PlainAlder11archiveSep 24

The research schedule increased the dosage two milligrams at four-week intervals. I lack medical training and rely solely on what happened to me plus extensive time spent researching prior to beginning in early January along with ongoing study. Should that approach suit your situation then fine. I have no information regarding the period before menopause. Everything here represents merely my viewpoint.

BrightCompass57archiveSep 24
↳ replying to @PlainAlder11

Raising the dose in small steps seems wiser to me because I can observe my own reactions. My system handles minor adjustments more readily. Those big drug makers almost never provide the ideal guidance on how often anything should be taken, probably by design.

PlainAlder11archiveSep 24
↳ replying to @BrightCompass57

Apparently that shows I'm not very clever. Just like before this comes from what my spouse and I have seen firsthand.

QuietAnchor73archiveSep 24
↳ replying to @PlainMarble21 (opening post)

People react uniquely to the increased amount of that agonist medication once it reaches a certain level. The unwanted reactions tend to show up more clearly past a particular threshold. These reactions often fade away on their own after several weeks pass. When they get overwhelming, reducing the amount for a short time and then increasing again later works for some. My own attempt at raising it higher led to issues, so I lowered it temporarily before settling at a middle level. Hormonal changes during that life stage add extra complications that aren't studied as much, particularly among guys. I doubt I could handle even a few days of what the females around me go through.

PlainAnchor66archiveSep 24

I have a couple of choices here. I could keep the present amount and push through the unease for one more week before checking again. Or I might insert an extra interval in the divided portions and test whether that added time improves how I feel since this is my personal experiment and nothing requires fitting the splits inside seven days. The last possibility is returning to the level I used before.

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