Participants discuss whether sublingual semaglutide works and note the lack of testing. One person shares a medical opinion that it falls short for weight loss or diabetes control compared with subcutaneous use. Others suggest alternatives like tablets or intranasal routes and debate reconstitution liquids for nasal or single-use applications.
What this discussion establishesWhether sublingual or intranasal routes could deliver usable doses versus standard injection
Still openActual absorption rates, dosing accuracy, or side-effect differences for non-injection methods
Nothing here is advice.
Has anyone tried giving semaglutide under the tongue? It is said to work with certain absorption aids. Multi-dose vials have been off limits for me because of an allergy to benzyl alcohol.
I have not. Have you looked into orforglipron tablets? They seem to be getting more attention in the grey market.
Many in the UK turn to sterile water when the other kind isn't available to them. That leads me to keep using semaglutide but from the tiniest containers I've noticed, some holding only two milligrams.
Without any checks performed yet, figuring out the result stays impossible.
This option seems preferable overall. Nasal delivery looks more logical than under the tongue if little time gets spent checking details. Similar compounds often get used that way and a paper recently covered nasal insulin helping with memory problems. So uptake of these larger molecules probably works okay yet still deserves a closer look through proper channels or an ai tool for academic papers. Figuring out the exact amount delivered could prove tricky so any trial would need a tiny initial amount followed by slow steps upward. Uptake would likely happen quicker than under the skin which might bring on queasiness right away and the brain could end up with more exposure than the usual shot. Plain water for mixing works fine here since the dose stays nasal. Another route involves taking single portions from small vials mixed only with water for shots which ends up inexpensive versus the usual bought versions and lower in monthly cost than most standard medicines. I wondered whether a reaction to the common preservative counts as a true allergy since the molecule itself stays small yet it turns out reactions can occur.
I need to point out how regular liquid differs from what flows from the tap. Clean fluid matters a lot when flushing the nose passages. Mentions of sinus cleaning tools always stress purified liquid. It struck me as unnecessary caution until reports of a person passing away after skipping that step. This leaves me puzzled about the cause since water meant for drinking undergoes treatment and checks.
It all hinges on what the goals are. My doctor mentioned that placing it under the tongue falls short compared to shots when trying to drop weight and it offers nothing for diabetes.
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