I've noticed some excitement around this on TikTok. It seems great and could help people who can't handle injections.
This would be incredible if it turns out to be effective.
The Holy Grail of weight loss?
Summary
Is GLP-1 gene therapy the breakthrough for permanent weight loss?
Forum users react to news of the first human GLP-1 gene therapy trial with a mix of excitement and caution. Some see potential for needle-free access while others highlight risks like pancreatitis, dosing challenges, permanent side effects, and multimillion-dollar costs. The thread notes the trial location and limited eligibility but offers no consensus on feasibility.
What this discussion establishes- Excitement centers on easier access without injections
- Insurance coverage and high cost seen as major barriers
- Safety worries include pancreas inflammation and irreversible effects
- Gene therapy for myostatin mentioned as a separate long-standing goal
- Trial is starting in the Netherlands with strict participation rules
Whether the therapy can safely produce therapeutic GLP-1 levels long-term without animal data or real-world proof
Nothing here is advice.
5 replies · 5 people
↳ replying to @CopperBeacon14
Should it reach the market, insurance probably won't cover it, making it too expensive. Oral versions might suit those avoiding shots, and it could require trying other treatments first.
Looks hopeful. Gene editing seems like where things are headed, though it's somewhat concerning. The study starts in the Netherlands, but unfortunately I don't meet the criteria to join.
A lasting solution would be nice. I'm unsure how it would function and whether animal tests have happened yet. Delivering it into the pancreas carries some risk of inflammation. It would also need to produce actual GLP-1 or something close, yet natural GLP-1 breaks down fast, so the therapy would require high output to match current drugs, which might lead to ongoing side effects if too many genes activate. Existing gene therapies already run into the millions.
It's good to see efforts on gene therapy for GLP-1. We've long hoped for something targeting myostatin to deal with bullies... like the bully whippet condition.
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