CommunityDosing & Titration

Tirz Week 3 Dosing Experiences

9 replies9 peopleApr 27, 2026☆ Follow
Summary

Should I increase from 2.5 mg tirzepatide at week 4 if appetite is already suppressed but scale weight has not moved yet?

Most participants advise staying at 2.5 mg while suppression remains strong and sides are present, tracking calories and activity to confirm a deficit, and only titrating slowly once suppression fades. Several report continued loss on the starting dose or after adding a second compound, and note that early water-weight drops or body recomposition can mask scale progress. Side effects are treated as the main signal for whether a higher dose will be tolerable.

What this discussion establishesWhere people disagree

Whether to follow a standard monthly increase or wait until suppression weakens; some favor the former for simplicity while others prefer the latter to minimize sides.

Still open

How long to remain on 2.5 mg before any increase becomes necessary for continued progress.

Nothing here is advice.

9 replies · 9 people
GreyWillow12archiveopening postApr 27

Hi everyone, I would like feedback and personal stories about tirz experiences and dosing. I am starting week 3 with no prior GLP use, taking 2.5 mg once weekly. Side effects are minor, mainly occasional nausea or acid reflux the day after the shot, which I handle with OTC remedies. Appetite stays low and food noise has dropped, yet I have seen no weight change despite regular exercise. Is it still too soon to expect noticeable loss? Should I move up to 5 mg anyway, or stay put while 2.5 mg feels sufficient?

SlowThistle36archiveApr 27

I began at 2.5 mg and remained there for four weeks with good appetite control similar to yours. Instead of raising tirz I added 1 mg of another compound to gain extra benefits while keeping the suppression from tirz. That combination gave a further drop in food noise. I have lost 20 lb so far, mostly water but some fat as well. I maintain a 1000-calorie deficit, walk at least five miles daily, and lift three or four times a week. Logging every calorie provides clear data on why the scale moves or stalls.

CopperSignal27archiveApr 27

With limited hunger and already some nausea on 2.5 mg, going to 5 mg will probably make nausea worse. It is difficult to judge from your description how severe the current nausea is. If your goal is substantial loss you will likely need a higher dose eventually, but there is no rush. You could try 5 mg and drop back if vomiting starts, or move more gradually to 3 or 3.5 mg. Side effects themselves are the clearest indicator of whether an increase will cause problems.

SharpCinder28archiveApr 27

Weight came off quickly for me at first before a stall set in. I started from my highest weight and followed an aggressive schedule set by my doctor. Some lose four or more pounds weekly even on just 1 mg of another medication. You might be experiencing recomp or other non-scale changes. Many options exist and can feel overwhelming, so staying consistent helps. Doses below 5 mg per week are not viewed as fully therapeutic, though microdosing works for some. My losses often line up with side effects, which I do not mind. I keep several OTC options plus a prescription anti-nausea medication on hand.

IronThistle42archiveApr 27
↳ replying to @GreyWillow12 (opening post)

When I faced the same question I remind myself there is no race unless a specific deadline exists. Most here agree that the lowest effective dose with the simplest approach is preferable for long-term well-being and cost. Focus on food choices, movement, and sleep remains essential alongside any medication.

SlowSparrow81archiveApr 27
↳ replying to @GreyWillow12 (opening post)

I am finishing week 5 on 2.5 mg. Suppression is still strong, possibly even better now than in week 3, and nausea plus fatigue have eased. I have dropped 5 kg while keeping up exercise. Since it continues to work I am not increasing the dose yet.

PlainTimber26archiveApr 27

I tried moving from 2.5 to 3.75 mg after four weeks while still having nausea. That was a mistake. Allow more time for the lower dose to accumulate before any increase, and avoid jumping straight to 5 mg if sides are already present.

NorthSparrow11archiveApr 27
↳ replying to @GreyWillow12 (opening post)

Tirz has worked well over the past year. I kept intake at TDEE minus 500 calories, never dropping below 1500 to avoid energy crashes. I raised the dose only when food noise returned, moving from 2.5 mg up to 10 mg where I have stayed for seven or eight months. Loss began right away. Tracking intake and adjusting the dose based on returning hunger is the approach I recommend most.

RustCompass19archiveApr 27

The monthly step-up schedule exists mainly because it is simple to remember. If suppression is still present there is little reason to double the dose at week 4, since levels may not have peaked yet. A better plan is to raise only when appetite control begins to fade, and to do so gradually.

GreyWillow12archiveMay 4
↳ replying to @RustCompass19

That advice matches what I was already leaning toward. Thank you.

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