Forum › Dosing & Titration

Best way to combine 5-Amino, SS-31, NAD+ and MOTS-c in the morning

8 replies3 peopleMay 28, 2026☆ Follow
Summary

What order should 5-Amino, SS-31, NAD+ and MOTS-c be taken together in the morning?

Users describe starting NAD+ first, then adding 5-Amino, with SS-31 introduced later for possible vision or energy benefits. One protocol spaces SS-31 and NAD+ before training, followed by 5-Amino and MOTS-c on workout days. Another runs 5-Amino daily for eight weeks, SS-31 for thirty days, MOTS-c three times weekly on cardio days, and NAD+ three times weekly on non-MOTS-c days, all fasted in the morning. People report better energy from the stack but adjust doses when higher amounts cause tiredness.

What this discussion establishesWhere people disagree

Whether SS-31 must come before MOTS-c and whether all four should be used on the same day

Still open

Exact daily sequence that works best for vision or energy gains

Nothing here is advice.

8 replies · 3 people
QuietKettle35archiveopening postMay 28

Hello all! Right now I'm taking the 5 aminos and then NAD+ half an hour later. What's the right way to include SS31 and MOTS-c? I've looked into it and everything's supposed to be morning stuff, but the sequence matters or maybe it's not good to combine them all. Appreciate any input.

LikeSame experienceReply
PatientFenwick91archiveMay 28

This looks like too many things at once. You probably won't be able to tell which one is helping if you add everything together. The question of SS31 before MOTS-c is still open, but I'm doing SS31 first and then MOTS-c later. NAD+ has been in the background for me already. I don't see a problem keeping it with either of the others. If you still want to add 5 amino on top, spacing it the way you mentioned should be fine.

LikeSame experienceReply
QuietKettle35archiveMay 28
↳ replying to @PatientFenwick91

Thanks. I wasn't planning to start them all at the same time. I did NAD+ for four weeks first, then 5 aminos for three weeks so far. My energy is much better than before, so I want to keep going but mainly add SS31 to check for vision improvements. Not trying to sound dumb, but I need to know the order on any given day, like 5 aminos, wait thirty minutes, then SS31, then NAD+?

LikeSame experienceReply
PatientFenwick91archiveMay 28
↳ replying to @QuietKettle35

Got it, that makes sense. Glad the energy improved. I didn't notice much from NAD+ until I added SS31. It hasn't done anything obvious for my vision but I feel better overall. It's not a dumb question. Everyone seems to run different protocols depending on their goal. For me, 5 amino and MOTS-c go before the gym, which ends up after SS31 and NAD+.

LikeSame experienceReply
QuietKettle35archiveMay 28
↳ replying to @PatientFenwick91

So on training days you do SS31 first, then NAD+, then 5 aminos and MOTS-c, or do you skip the last two together?

LikeSame experienceReply
WarmSparrow60archiveMay 28

5-Amino at 5 mg every day for eight weeks then a month off. SS-31 at 5 mg for thirty days then a month off. MOTS-c at 5 mg three times a week only on cardio days. NAD+ at 100 mg three times a week, never on the same day as MOTS-c. All taken fasted in the morning. The first two help running feel better, the last one helps lifting feel better.

LikeSame experienceReply
QuietKettle35archiveMay 28
↳ replying to @WarmSparrow60

Hi, thanks a lot. Just to check, do you take SS31 at the same time as 5 aminos, or do you switch to 5 aminos only during the break from SS31?

LikeSame experienceReply
WarmSparrow60archiveMay 28
↳ replying to @QuietKettle35

Together. For me 5 amino feels like two really clean espressos and has become one of my regular compounds. I only take a break so I don't lose sensitivity to it.

LikeSame experienceReply
QuietKettle35archiveMay 28
↳ replying to @WarmSparrow60

Nice. I notice the difference with 5 aminos and NAD+ too, but I only use 2.5 mg of the first one, five days on and two off, and NAD+ every day at 25 mg. When I tried 50 mg three times a week it didn't suit me and left me tired for a couple of hours after the shot.

LikeSame experienceReply

Related discussions

Add your experience

If you have tried it, this topic is still open. Sign in to reply — it takes a minute.

Sign inCreate an account