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AMA on resistant starch fibers Akkermansia peptides and allulose dosing

106 replies40 peopleMay 7, 2026☆ Follow
Summary

what dosages combinations and effects of fibers resistant starch polyphenols and oral peptides have on gut microbiome Akkermansia weight and related metabolism

The thread explores practical mixes of psyllium inulin FOS allulose and resistant starch along with polyphenol routes and peptide options for gut repair. Expert input covers cultivation limits Akkermansia responses to apple pectin or green banana thyroid regulation of energy and safety comparisons like allulose versus erythritol. Personal reports note fiber benefits antibiotic setbacks and variable peptide sourcing while medical questions receive redirects.

What this discussion establishesWhere people disagree

long-term fiber needs and commercial peptide sourcing

Still open

optimal personal fiber mixes and weight-specific outcomes

Nothing here is advice.

106 replies · 40 people · page 1 of 3
KeenKettle50archiveopening postMay 7

Basically the title. I earned my PhD in novel food innovation and have spent the last few years creating fresh dietary prebiotic fibers aimed at varied gut health. Thursday night and I'm bored, so ask me almost anything. Mods, delete if this isn't allowed. Sorry in advance. NOTE: I cannot give any explicit nutritional advice, so please don't ask things like how much protein I should eat or whether I should exercise.

SharpCinder28archiveMay 7

To avoid diarrhea or constipation from GLPs, the usual tip is soluble fiber such as psyllium husk. Any other fiber suggestions for handling diarrhea or constipation caused by GLPs?

KeenKettle50archiveMay 7
↳ replying to @SharpCinder28

Insoluble fibers like green bananas and viscous fibers such as oat beta glucans can help stools by adding bulk and moisture. They also support gut bacteria overall.

KeenQuill92archiveMay 7

Nerd here. How do you measure success for the new prebiotics you're developing? Are you looking at the microbiota, some imaging method? Also, what kinds of hypotheses interest you most in this area?

KeenKettle50archiveMay 7
↳ replying to @KeenQuill92

It depends on market needs, clinical evidence, and customer awareness. Our company stays conservative on scientific standards and checks the quality of existing clinical data closely. A marketing team tracks business needs, often in million-dollar figures. You don't really test hypotheses like an academic would because business priorities come first. We did run a clinical trial on a new fiber for metabolic benefits and natural GLP-1 responses, but results were mixed. Right now the big push is on satiety, natural GLP-1 responses, and metabolic health benefits delivered through a fiber that works inside actual food products.

AmberSignal37archiveMay 7
↳ replying to @KeenKettle50 (opening post)

I think gut health ties into overall health, even mental health. What are your thoughts? What should people add or remove from their diet to get the best gut results?

LevelBramble14archiveMay 8

I've been wondering whether that peptide can truly help with intestinal problems.

KeenKettle50archiveMay 8
↳ replying to @AmberSignal37

Yes, definitely. Think of the body as a factory and the colon as waste management. If the border between waste management and the rest of the body breaks down, metabolic toxins like uremic toxins, branched fatty acids, and ammonia leak into the factory and cause problems. Leaky gut is real. Bacteria in the gut also affect enterocyte gene expression, keep the gut lining intact, support neurological health, suppress pathogens like E. coli or Strep, and produce vitamins. Probiotics alone don't work well because you're sending troops without supplies; they need fibers that suit your bacteria to stay around. We have hundreds or thousands of species, each reacting differently to different fibers. Eating more fiber and cutting back on excess fat and sugar helps.

NorthMeadow54archiveMay 8
↳ replying to @KeenKettle50 (opening post)

I'm curious whether fermented cabbage dishes and yogurt with that reuteri strain continue ranking as the top picks for intestinal wellness or if superior choices have appeared since.

PlainAlder11archiveMay 8

Wife and I add a scoop of Oat Bran to our lunchtime protein shake. Is that good fiber and worth doing?

KeenKettle50archiveMay 8
↳ replying to @NorthMeadow54

Kimchi works as a synbiotic with prebiotic cabbage and probiotic lactic acid bacteria, but in my view those bacteria are only okay. They bully pathogens effectively but that's mostly it. Same with yogurt. Keep eating them, but I would also add green banana resistant starch and oat brans.

KeenKettle50archiveMay 8
↳ replying to @PlainAlder11

Yes! Oat brans help diversify good bacteria like Bacteroides and Parabacteroides that then make use of other fibers too.

RustSignal22archiveMay 8

How does fiber affect insulin sensitivity, and what about fiber in a pre-workout carb meal for steady energy? Also, two people with identical calorie needs, body composition, workouts, and meals for a year both enter a deficit with the same high-protein diet. Person A adds 25-30 g fiber while Person B does not. After one year, will one lose more fat or keep more lean mass? Any differences you know of?

KeenKettle50archiveMay 8

Oof, that moves into endocrinology so I can't cover it fully. Fibers turn into short-chain fatty acids like acetate, propionate, and butyrate during fermentation. These affect gene expression in organs such as the liver. Acetate and propionate lower gluconeogenesis in the liver, which helps control glucose and favors glycogenesis. Short-chain fatty acids also raise anti-inflammatory cytokines and lower inflammatory ones that hurt insulin signaling. Hope that helps. For the second question, exact outcomes are hard to pin down from diet alone because gut flora differs between people. Still, high-protein meals without fiber would likely shift fermentation from saccharolytic to proteolytic, producing toxins like urea, sulfur compounds, and branched-chain fatty acids that can harm tissues.

KeenLantern58archiveMay 8
↳ replying to @KeenKettle50 (opening post)

Any thoughts on KPV or KLOW? My wife has long-standing stomach issues. I don't want her to try them because of a recent tumor, but I've read they might have healing effects.

KeenKettle50archiveMay 8
↳ replying to @KeenLantern58

I've got no clue on those items since they don't count as something you eat. Are you meaning the real belly organ? The smaller or bigger section of the bowel? What precisely are those particular problems?

BlueSignal49archiveMay 8

Will those protein bars make me leak?

KeenKettle50archiveMay 8
↳ replying to @BlueSignal49

Lol, probably not. But if they contain maltitol, polydextrose, sorbitol or other fast-fermenting sugar alcohols or oligosaccharides, you might end up with a big release of gas.

CopperAlder51archiveMay 8

You mentioned green bananas. I saw an article saying inulin in them helps digestion and overall health. I've been adding two teaspoons of powdered inulin to my coffee each morning. Is that enough? I tried green bananas but I'll skip those.

KeenKettle50archiveMay 8

Powdered green bananas exist and I recommend them. They aren't the tastiest but blend well in apple or strawberry smoothies. Inulin and green banana resistant starches differ. Inulin is a fructan, a chain of fructose. Resistant starch in green banana is type 2: crystalline granules that resist digestion unless cooked and act as fiber. Inulin ferments quickly in the proximal colon. It is seen as a gold-standard fiber now, yet studies show it mainly helps people with metabolic issues like impaired glucose or high cholesterol, not healthy people. It feeds bifidobacteria, which support immunity, but broader health gains are limited. Because it only ferments in the first part of the colon, it leaves the middle and distal sections untouched, and the distal colon is where colon cancer often appears. Resistant starch from green banana ferments more slowly through the colon.

KeenLantern58archiveMay 8
↳ replying to @KeenKettle50

My mistake, I figured your presence here meant the discussion covered peptides as well.

CopperAlder51archiveMay 8
↳ replying to @KeenKettle50

Thanks for the detailed explanation. I'll look for powdered green bananas!

KeenKettle50archiveMay 8
↳ replying to @AmberSignal37

Keeping things simple works fine for everyday wellness. Produce like fruits and greens offers solid options, though I tend to favor berries along with apples. The soft parts of fruits contain various types of fiber such as pectin, cellulose, arabinogalactans, and xyloglucan. Having several kinds together seems preferable compared to relying on just one kind. When aiming for more specific effects, the options I tend to look at include oat bran, powdered green bananas, and those oligosaccharides to support metabolism, promote fullness, and help with weight. Fibers from carrots can lessen gas issues. Beta glucans from yeast may aid immune function. Broken down galactomannan from guar, along with resistant starch from potatoes, can improve bowel movements. Inulin works for general upkeep, though I skip it during gut inflammation. Those particular oligosaccharides do not qualify as fiber under certain official standards, even with evidence of their positive effects. Some additional types exist that underwent testing yet remain inaccessible to regular buyers since they were made only for studies and cost too much.

KeenKettle50archiveMay 8
↳ replying to @KeenLantern58

I'm fairly new to peptides myself and only have experience with a few.

CopperSignal27archiveMay 8

I know I'm not the expert, but psyllium husk stands out as the only fiber I've seen that can actually ease diarrhea. There are papers on it. With ulcerative colitis in remission but still having symptoms plus possible IBS-D, it helped me and seemed to reduce pain too, until GLP drugs slowed my gut enough to cause constipation and I had to stop. It could still help people dealing with GLP-related diarrhea, which is common.

ClearQuill84archiveMay 8

What are the worst food products for gut microflora? I assume fast food and heavily processed items, but maybe there are others I don't know about.

NorthMeadow54archiveMay 8
↳ replying to @KeenKettle50

I eat a ketogenic diet and stay almost completely fart-free with no bad bowel movements and steady energy. I have a little yogurt and kimchi daily and sometimes keto bread, but it's hard to justify every day because it costs more than a pound of pastured meat.

PatientHarbour23archiveMay 8
↳ replying to @BlueSignal49

Anal leakage? Too many of them will definitely do that.

SlowLedger42archiveMay 8
↳ replying to @KeenKettle50 (opening post)

In what way are you developing new fibers? Chemically altering existing ones, making new structures, looking at fibers from uncommon plants, or testing blends? You focus on commercial use rather than pure research, so I assume the goal is something patentable or protectable, unlike studying rare plants that anyone could copy. You also mention fiber in a food matrix, which suggests keeping the food's natural structure instead of just stirring in a supplement. Is that right, or is there tech that rebuilds an effective matrix in processed foods to slow absorption? Simple mixing can do some of that, but your mention of matrices caught my attention.

SharpHarbour71archiveMay 8

Is it okay to eat a couple tablespoons of psyllium husk every day? What are the best fibers for gut health?

KeenKettle50archiveMay 8
↳ replying to @NorthMeadow54

I make my own keto bread and have been refining the recipe for seven years outside of work. A recent meta-analysis looked at different diets and found lack of fiber was the common factor in poor health outcomes. If you get enough fiber you should be fine.

SlowLedger42archiveMay 8
↳ replying to @KeenKettle50

Those studies are a bit more debatable than they first appear. There aren't many true low-carb trials to draw from. Most compare cutting carbs from 50 percent to 30 percent of calories, which is interesting but doesn't tell us what happens on an actual low-carb or keto diet. I don't have a strong view either way, just noting the limited modern research on keto diets.

KeenKettle50archiveMay 8
↳ replying to @CopperSignal27

Psyllium is interesting. It is a glucurono-arabinoxylan that is insoluble and unfermentable, yet it can still shift gut populations. Our company does not create fibers through chemical synthesis, harsh acid hydrolysis, grafting, or recombinant bacteria. There are gentler ways to modify fibers without those methods. Patents cover not only processes but also the physical and chemical traits of the final products. We check the competitive landscape to avoid existing patents. When I say food matrices I mean the fiber must fit into real foods without hurting texture, color, or taste. That is why inulin, fructo-oligosaccharides, and soluble corn fiber are popular: they are flavorless, cheap, colorless, low-viscosity, and highly soluble.

KeenKettle50archiveMay 8
↳ replying to @SlowLedger42

Yeah, that's my issue with keto diet studies too. Keto is just defined as high-fat low-carb, so people follow it in all sorts of ways. You can't expect the same results from someone eating steak and bacon daily versus someone eating avocado, spinach, and lean chicken.

KeenKettle50archiveMay 8
↳ replying to @SharpHarbour71

See my earlier reply. I don't know of any single food that ruins the gut; if it did it wouldn't count as food. It comes down to habits. Studies keep showing that high-fat and high-sugar diets lower good bacteria and raise bad ones like proteobacteria. More accurately, the lack of fiber is the real driver rather than the fat and sugar themselves.

RustCompass19archiveMay 8

Super interesting thread. A few questions if you don't mind: I suspect SIBO might be behind my Laryngopharyngeal reflux. What's the best test for it? I've had bloating and constipation since childhood; twenty years later things are better but I still get IBS when traveling, with bloating and headaches on long flights. Could they be linked? I started 200 mL of milk kefir plus chia seeds and saw big improvement in bowel movements. Is there a right amount of probiotics? Is adding variety like kimchi always better?

QuietMarble97archiveMay 8

I am searching for resistant starches from green bananas and notice plenty of organic banana flour along with organic green banana flour options. Do the flours match the powders exactly or must I seek out items labeled specifically as resistant starch from green bananas?

KeenKettle50archiveMay 8
↳ replying to @RustCompass19

I'm not qualified to give medical advice. Bloating and constipation are common ongoing signs of a compromised gut. Have you spoken with doctors? What did they say? IBS is tricky because one possible cause is missing butyric-acid producing bacteria that can't be given as probiotics since they are anaerobic. Prebiotics may not help in that case either. There is no way to know the right amount of probiotics because we don't know how many will colonize or what your starting bacterial mix is. What you're doing seems to be helping since kefir has diverse probiotics beyond lactic acid bacteria and chia seeds provide gelling polysaccharides that can firm stools. Have you tried oat brans? If you want kimchi, look for white kimchi at Korean markets because it is milder.

KeenKettle50archiveMay 8
↳ replying to @QuietMarble97

You should search specifically for green banana flour. The organic banana flour version is likely just ripe bananas that got dried and ground, which ends up tasting better but with lower fiber levels.

RustCompass19archiveMay 8
↳ replying to @KeenKettle50

I never spoke with doctors about the bloating or IBS since those symptoms are so broad that I preferred checking options on my own first and maybe seeing a specialist once I had more clarity. Still, adding fibers changed things a lot. In the past three months I have also been on Tirzepatide along with BPC and KPV, and I think those helped too.

LevelWillow41archiveMay 9
↳ replying to @KeenKettle50

Would plantain flour work the same as green banana flour? Also, how much of either should someone normally take?

KeenKettle50archiveMay 9

I have not checked it closely, but a quick look at table 1 suggests plantain flour can reach up to 50 percent resistant starch. Even so, there is no certainty it will deliver the same microbiome or health effects seen with green banana flours.

BrightSignal52archiveMay 9
↳ replying to @KeenKettle50 (opening post)

What do you think about beans for fiber? Some anti-inflammatory diets recommend avoiding them, but I soak dried black beans overnight to cut lectins and would like your view.

KeenKettle50archiveMay 9
↳ replying to @BrightSignal52

Beans are fine. Their fibers usually include cellulose, fructans, some arabinoxylan, and the fast-fermenting raffinose, stachyose, and verbascose. They are not the best choice though because they can cause strong gas. Lectins are proteins that bind carbs and break down with heat, so they should not affect you much. I have heard of lectin-free diets but have not seen real studies on them.

SharpBramble33archiveMay 9

Wow, I thought I knew a fair bit until this thread made me realize how much more there is.

SharpBramble33archiveMay 9
↳ replying to @KeenKettle50

We already know how knowledgeable you are, but thanks for being upfront about not having experience with those peptides or compounds.

SlowSignal40archiveMay 9

I am here as a final option because someone nearby is dealing with extreme flatulence that feels like a worldwide problem. The hydrogen sulfide could create acid rain in Virginia, and during my six years in Toronto the weather stayed unusually warm with no explanation until I realized methane is far stronger than carbon dioxide as a greenhouse gas. Skip the mild carrot fibers even though carrots are this person's top vegetable and they could eat fields of them like rabbits on the loose. I need something stronger to stop the issue completely, like a total knockout move with no holding back.

KeenKettle50archiveMay 9
↳ replying to @SlowSignal40

It sounds like the person should wipe out their gut bacteria entirely and receive a fecal transplant from someone healthy.

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AMA on resistant starch fibers Akkermansia peptides and allulose dosing · ZyraTrack Community