Clinical trials are looking at combinations now. Tirz plus elora seems especially promising while sema plus cag looks weaker. If the downsides outweighed the upsides the studies would probably stop. Any drug has possible drawbacks. Skipping cagri is fairly common because its reputation has faded some. This site has lots of personal stories about stacking GLPs, cagri and the like. Whether it's good or bad is like asking if Gala apples are good, people just have their own preferences.
As the title asks, is stacking positive or negative? People do it, but what are the possible downsides? It's usually tried when one GLP isn't curbing appetite or sustaining weight loss, so another gets added, and I've seen this across the GLPs. I asked someone on another platform why they added a second GLP instead of trying cagrilintide first and got no clear reason. I haven't found studies on multi-GLP use, only single GLP. In my view it might help short term if sides stay tolerable, but those sides could persist or worsen. Longer term it might hurt more once the goal is met and maintenance begins, especially for insulin resistance and metabolic function. I don't know anyone who's done it and haven't tried it myself, just thoughts. Any feedback or experiences welcome.