ForumDosing & Titration

Switching from Tirzepatide to Retatrutide Shows Limited Effects at Moderate Doses

5 replies5 peopleNov 15, 2025☆ Follow
Summary

Why does retatrutide produce little appetite suppression or weight loss after switching from tirzepatide, and what doses are needed?

Users report stable weight and minimal appetite effects when moving from tirzepatide doses around 6-15 mg to retatrutide at 5-7 mg. Some regain a few pounds initially or see only slow loss of 0.5-1 lb per week. Escalating retatrutide to 12 mg or adding cagrilintide restored suppression for certain individuals. More energy on retatrutide was noted compared to tirzepatide.

What this discussion establishesStill open

Whether a low-potency batch explains the lack of effect or if higher retatrutide doses are routinely needed after tirzepatide.

Nothing here is advice.

5 replies · 5 people
RustAlder38archiveopening postNov 15, 2025

Looking for some thoughts on this. Maybe my current batch isn't as strong? On tirzepatide I dropped 30 pounds without needing high amounts, topping out at 6mg weekly. It really cut my appetite, reduced food thoughts, and even limited how much beer I could drink. Switched to retatrutide starting at 3mg per week, now up to 6mg after a month. Weight hasn't moved much. More energy has led to more exercise but no big changes. Has anyone switched from tirzepatide and can share thoughts on dosing? Wondering if what I received might have a problem, though the source seemed reliable based on their quick replies and reputation.

SteadyLantern42archiveNov 15, 2025

After reaching the top dose of tirz following a full year my progress halted once 83 pounds came off. Moving over to reta starting at 5 mgs led to adding 2 pounds across three weeks along with no hunger control at all. Raising the amount to 7 mgs produced only slight hunger control. Adding 0.5 mgs of cagri later brought the hunger control back and dropped those 2 pounds during the first week. My own view on reta stays mixed since the scale keeps moving downward but only at a slow pace of half a pound to a pound in a strong week.

SlowLantern99archiveNov 15, 2025

I questioned the reason for switching substances. My time with the initial compound spanned slightly more than twenty-four months, remaining at maximum strength after the opening period of roughly seven months, until halting towards the close of twenty twenty-four following a stall exceeding two months. After pausing for approximately three months, I initiated the alternative compound last April. Because effects were absent, I quickly raised the dosage levels, and upon the fourth administration I reached twelve milligrams where the desired response returned. Confirmation via analysis indicated the material's potency, slightly exceeding thirteen milligrams per unit on average, meaning I merely needed to identify the effective level for my system. Essentially, persist with increases until activity resumes.

RustAlder38archiveNov 15, 2025
↳ replying to @SteadyLantern42

I wonder what Cagri even refers to. One upside I've felt involves far greater vitality while taking it. Reducing glucose levels before left me drained instead. Still, bumping up the amount could bring back that same fatigue. Your observation lines up with how I see things. I'm considering moving my intake to eight milligrams. Later stage studies aren't out so far, yet it looks like a medium level of one calls for a medium level of the other.

PatientQuill30archiveNov 15, 2025
↳ replying to @SlowLantern99

Do people usually take a pause before switching over to different peptides? I'm thinking about moving from tirz over to reta in the near future. Still haven't reached the top dose on tirz, sitting at 7.5mg right now, though reta seems like it might be better. Thanks.

AmberAnchor10archiveNov 17, 2025
↳ replying to @RustAlder38

It turns out this matches another compound people mention. Looking through discussions here gave me plenty of details on the subject.

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