Reta skin sensitivity!!!

I get this too on reta and it has kept me from going above 3.5 mg a week. No magic fixes here, but regular Advil or similar helps along with lidocaine or hydrocortisone cream, though maybe not so much for the hair follicles.

I got that sunburn-like feeling on my stomach and back after raising my tirz dose. It hung around for about a month before finally disappearing.

I had the same thing around that dose. The only thing that helped me was taking roughly a ten-day break to let levels drop, then restarting at a lower dose. I've seen others say they just kept going and it eventually passed.

If it's that unpleasant you will probably need to lower the dose. Splitting might help if it's only bad right after the shot, but not if it lasts all week. Plenty of people here say it slowly fades over time, so you might be able to raise doses again after a month or two once it settles. I had some episodes while quickly increasing tirz, but now I get a milder version consistently on 15.75 mg tirz plus 5 mg reta weekly. I can't raise the reta at all without it getting much worse. Antihistamines don't seem to explain it since the problem is clearly GLP-1 related yet shows up more with reta.

I switched to insulin pens and tested one first with only a small deviation. Last Monday I used it for what I thought was 4 mg of retatrutide. From Wednesday onward I had very sensitive skin and lots of itching, which is now easing up. Retesting showed the pen overshoots because of the spring, so I likely got 6-7 mg. Conclusion is that raising the dose too fast causes strong side effects. Any tips for the skin issue?

I always called it a windburn feeling, like holding your arm out the car window too long. The good news is you adapt and it goes away, at least in my case.

I've had this skin sensitivity since starting reta nearly eight weeks ago. It's still there but has eased a bit in the last two weeks. Still annoying, but I'm getting closer to my goal weight so I can handle it.

It started for me at 6 mg. I lost weight fast at 8 mg and just dealt with it. Once I dropped to 4 mg for maintenance it went away. It's irritating but the weight loss mattered to me. You can either tough it out and hope a lower dose works later, or switch to something else.

Yeah it's awful but it does go away. I was close to quitting reta and then it just stopped.

I used reta for six weeks from a US source, then switched sources on week seven and got hives two days after the first new dose. I was also on day three of enclomiphene when the hives appeared. ChatGPT pointed to the enclo as the likely cause. I took Zyrtec twice daily, stopped the enclo, and symptoms cleared in three days. I've kept the Zyrtec going for ten days out of caution and will stop it today before my next reta dose tomorrow. Hoping it's not a reta allergy, but I'll know soon. Before the enclo I noticed warm skin but never hives.

I lived with the condition over many months and adapted to its presence. Out of nowhere it was no longer there. Physical activity provided the single form of relief for how I felt throughout.

Might be relevant. I'm on 15.75 mg tirz and 5 mg reta split into twice-daily doses. I always thought the sensitivity came only from reta because tiny increases made it much worse. I hadn't changed the tirz dose since reaching 15 mg, but adding an extra 1 mg of it the other day made the sensitivity just as bad as extra reta does. Still no idea what the receptors are doing, and I haven't found any research on it.

This is the only side effect that made me consider actually quitting instead of just lowering the dose and toughing it out. There were some rough weeks at every step, but in my experience it fades if you stay at a dose long enough. Because of all the sides combined I skipped a shot after week two at 4 mg and kind of reset. Skipping gave a nice break and let me feel normal again for the first time in months.

Out of everything this bothers my RS the most. The sheets covering my RS remind me of something warm and cozy. Good thing according to what others said it fades once my RS gets used to the amount.

Same here, skin sensitivity from the start. After three weeks it seems a lot less. Some days are worse than others, but I'm a bit scared to titrate up because of it.

Had the sunburn feeling on my face for the first time with this week's dose. Usually I get intense itching between my shoulder blades. For me a shot of 500 mcg to 1 mg of KPV lessens symptoms within an hour. Some people have luck with it, some don't, but it works 100 percent for me.

Four milligrams caused the effects to feel quite strong on occasion. Neither zinc picolinate nor antihistamines brought any relief at all. The whole thing cleared up by itself after roughly thirty days.

This week I noticed my skin became sensitive all of a sudden. After going up to eight units the next day it seemed like a mild burn from the sun at that event lasting four days. With the alcohol and exposure once back it was noticeable across my body. Before reaching that level I hadn't experienced anything like it. Thinking about lowering it slightly in the coming days.

I'm experiencing it again the past two weeks since going up to 6 mg.

The effect from what I took is fading bit by bit. It began for me on April tenth and now recedes at a gradual pace I can notice at this moment. By mistake I ended up taking more than planned over a short period. I aimed for four milligrams but suspect the amount was closer to six or eight since I have no clear recollection.