Victoza served a purpose before other options existed. It simply does not support weight loss well, which matches what you found, because blood levels swing too much. Begin reta at 1-2 mg to gauge response, since it can raise heart rate and hurt sleep early. The 1.8 mg Victoza dose is already substantial, so faster increases should be tolerable. I am not directing anyone, but I moved from 11 mg tirz down while adding reta at 1 mg and raised it by 1 mg weekly up to 8 mg with minimal problems.
I've been on 1.8 mg Victoza every day after previously using Ozempic, totaling about eighteen months. My A1C numbers improved but weight loss stayed minimal. As someone with lifelong diabetes who still injects insulin, this approach isn't delivering results. Given the resistance and long GLP-1 exposure, would starting at 2 mg then moving to 2 mg twice weekly if needed reach a useful level around 4-8 mg? I suspect I could begin at 4-6 mg without issues. What do others think?