CommunityCompound Experiences

Comparing Reta and Tirz: Which one wins for me

31 replies22 peopleApr 3, 2026☆ Follow
Summary

How do retatrutide and tirzepatide compare for appetite control, side effects, and weight loss when used alone or together?

Users report tirzepatide often delivers stronger, cleaner appetite suppression with fewer issues like allodynia or elevated heart rate, while retatrutide can cause food aversion, nausea, and restlessness at higher doses. Some alternate the two or add low-dose glucagon agonists to reduce stalls and side effects, though results vary by person. Several stay with tirzepatide after trying retatrutide and finding it less tolerable, while others prefer retatrutide for fat loss once they adapt.

What this discussion establishesWhere people disagree

Whether retatrutide's glucagon effect is worth the sides compared with tirzepatide's cleaner profile, and if low-dose stacking adds meaningful benefit.

Still open

Optimal long-term dosing strategies or how results hold once users reach goal weight.

Nothing here is advice.

31 replies · 22 people
SharpHarbour71archiveopening postApr 3

I could only reach 4 mg weekly on Reta before allodynia and anhedonia hit hard. The glucagon action seems to be the culprit in my case, since my resting heart rate climbed 14 bpm and I felt off overall. Weight came off, yet mainly because food started tasting gross and the idea of eating turned me off, plus plenty of nausea. Tirz feels far better. Appetite gets crushed so thoroughly it is like having ten gastric bypasses; I feel stuffed even when I still want food and cannot picture eating more. At 3.5 mg weekly there is no allodynia, anhedonia is milder, heart rate is lower, and everything feels smoother.

WarmAlder92archiveApr 3

Adding a little Survo can bring some glucagon activity into the mix. I dropped from 7 mg weekly Tirz down to 5 mg while adding 1 mg of the other compound and kept the benefits with almost no extra sides.

PatientAnchor52archiveApr 3
↳ replying to @SharpHarbour71 (opening post)

I run both, Reta on Saturday and Tirz on Wednesday, and see similar effects to what you described. Adding HGH seems to work especially well alongside Tirz. Using only one at a time tends to produce stalls, so switching between them helps me keep moving.

SteadyTimber65archiveApr 3

Food sounds repulsive to me too, so I stopped increasing the dose. At week seven I stayed put because my body seemed to think it was starving and weight loss slowed. Holding at 10 mg for another week or two has me feeling better, eating some protein, and drinking more water. Appetite stays controlled but the scale is not moving like it did early on with Sema. I have Reta on hand and may try it after a break from Tirz, or simply wait longer at the current level.

PatientAnchor52archiveApr 3
↳ replying to @WarmAlder92

I have been looking to try that combination myself after hearing positive reports.

SharpCinder28archiveApr 4

Cost-wise it makes little sense to build a version of Reta with other compounds when straight Tirz plus Reta already works, though variety is still interesting.

AmberWillow98archiveApr 4

I rotate one compound on and one off. My wife prefers Reta because it removes food noise completely, while I still notice some noise when using only Reta.

LevelSignal46archiveApr 4

Thanks for sharing; I was already considering adding Tirz to my next order.

PlainTimber78archiveApr 4
↳ replying to @PatientAnchor52

What doses are you using? I am on 5 mg Reta and 5 mg Tirz but have not noticed much from the Tirz yet.

PatientAnchor52archiveApr 4
↳ replying to @PlainTimber78

I use 5 mg Tirz and 4 mg Reta. Reta alone barely touches appetite, and raising it brings too much skin sensitivity. Tirz handles cravings well; I stayed at 2.5 mg of it by itself for three months.

PatientAnchor52archiveApr 4
↳ replying to @SharpCinder28

That is why I keep kits of Tirz and Reta rather than the other option. Part of me still wants to test the mixed approach, so I will probably pick up one vial to try.

WarmAlder42archiveApr 4
↳ replying to @SharpHarbour71 (opening post)

Sounds exactly like my situation. I was on Tirz alone, added Reta to break a plateau, reached 4 mg, then stopped because of the same issues: felt off, resting heart rate up, sleep poor, colder, and eating became difficult. Only three pounds lost over seven weeks, so not worth it. Back on Tirz alone I feel fine and in control again. I will try a modest increase in Tirz before considering anything else.

CopperAlder51archiveApr 4

Reta suits me well. Skin sensitivity lasted a month and constipation appeared briefly, but nothing else. I have been at 10 mg for two months and am down 70 lb so far.

PatientAnchor52archiveApr 4
↳ replying to @CopperAlder51

Glad it is working that well. One advantage of handling this ourselves is the ability to switch compounds without needing approval.

SharpCinder28archiveApr 6
↳ replying to @WarmAlder92

A partial version using actual Reta as well.

GreySparrow51archiveApr 6

I wish the dose calculators allowed overlaying several compounds at once; the ones I checked lacked that feature.

WryBramble37archiveApr 6

Reta worked best for my last ten pounds. The GIP and glucagon activity seem to break down fat and sugar effectively. You can still eat without feeling starved; the scale and body-fat measurements are the real indicators. Adding Tirz reduces the glucagon component.

WarmSparrow60archiveApr 6

Watching Reta gain attention over the past year has been interesting yet ultimately not enough to pull me away from Tirz. The sourcing side added to the hype, but my results with Tirz have been strong and side-effect light. I never experienced allodynia, which appears common with Reta and may explain higher dropout rates in studies. The glucagon-to-GIP balance still seems unclear. Switching from Tirz to Reta would feel like trading something reliable for an unknown with more risk.

GreenMarble76archiveApr 6
↳ replying to @GreySparrow51

Smart Peptide Tracker works on both Android and iOS and handles multiple compounds plus inventory tracking.

BrightSignal76archiveApr 6

My current protocol is 8 mg Reta plus 1 mg Cagri. At 12 mg Reta sleep suffered and at 8 mg I stalled for three months, so I added Cagri. Appetite control is now balanced enough to hit daily protein and keep energy for workouts.

GreySparrow51archiveApr 6
↳ replying to @GreenMarble76

I tried the app but did not see any half-life curves. Does the pro version add that feature?

PatientBeacon15archiveApr 6

I track concentrations myself in a spreadsheet. With a six-day half-life the level drops by a factor of 2^(-1/6) each day, and you can chart it however you like.

GreenMarble76archiveApr 7
↳ replying to @GreySparrow51

I have the pro version, though the stack view may have been available earlier. Look under My Stack and scroll down a bit.

PlainKettle23archiveApr 7
↳ replying to @PatientAnchor52

I also had skin sensitivity when first increasing the dose. It faded after about two weeks once I moved from 2 mg to 4 mg weekly. Now at 10 mg over six months it has not returned.

RustKettle37archiveApr 7
↳ replying to @WarmAlder92

The low motivation at 1 mg twice weekly is too much for me. The reduced interest in food is tolerable, but the effect on drive is not, so I will try Tirz next.

BrightTimber93archiveApr 7

After eight weeks on Tirz I see no reason to add anything else. Appetite suppression has been strong from the start; I often stop midway through a meal feeling full. I am still on 2.5 mg and will increase soon as the effect softens slightly, which is expected.

WarmWillow50archiveApr 7
↳ replying to @BrightTimber93

Results differ between people. I have stayed at 5 mg for months with the same strength of effect, while my sister needed to move to 7.5 mg after two months and has done well there.

AmberAlder58archiveApr 7
↳ replying to @WarmSparrow60

The tribal tone is not necessary. People respond differently and have different goals, so what suits one person may not suit another. No need to frame it as a contest between compounds.

BlueLantern35archiveApr 7
↳ replying to @WarmAlder92

What is Survo? I hope it is not another tempting peptide.

WarmSparrow60archiveApr 7
↳ replying to @AmberAlder58

I wrote the original post. It was simply my observation based on my own data, not an attempt to start an argument. I have lost 33.6 percent of my starting weight in 46 weeks on Tirz and see no reason to switch. The point was that the alternative is not automatically better.

WarmAlder92archiveApr 7
↳ replying to @BlueLantern35

Survo is survodutide, a once-weekly GLP-1 and glucagon agonist. Mazdutide is similar. Plenty of peptides exist, so research dosing carefully because information varies in quality. There used to be a subreddit focused on that mixed approach, though its current status is unclear.

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Comparing Reta and Tirz: Which one wins for me · ZyraTrack Community