CommunitySide Effects

Tirz and insomnia

8 replies9 peopleAug 28, 2025☆ Follow
Summary

Does Tirzepatide cause insomnia or other sleep changes?

Users report mixed effects on sleep after starting Tirz. Several noticed insomnia especially in the first weeks or right after injections, while others saw no change or even deeper fatigue. A few with prior sleep issues found the problem more noticeable under calorie restriction and added aids after consulting doctors. One user tracking apnea data observed more central events that persisted.

What this discussion establishesWhere people disagree

Some experience insomnia or disrupted nights while others report unchanged or improved sleep and fatigue instead.

Still open

Whether the sleep effects settle with time or dose adjustment remains open.

Nothing here is advice.

8 replies · 9 people
SteadyThistle59archiveopening postAug 28, 2025

Has Tirz caused insomnia for anyone else? I'm only getting about five hours of sleep and don't seem to require any more. It could be due to general stress or perhaps the medication itself.

NorthCinder83archiveAug 28, 2025

Even after a full year on Tirz at a dose higher than the maximum, I continue to get a complete night's rest, sometimes eight or nine hours.

ClearLantern88archiveAug 29, 2025
↳ replying to @SteadyThistle59 (opening post)

Yes, that happened to me at the beginning. It still occurs occasionally right after my injection.

WryCompass39archiveAug 29, 2025

I had the same issue for a period right after beginning, but now I'm sleeping fine again.

ClearThistle50archiveJan 28

Tirz has ruined my sleep. I already deal with insomnia, but one night I stayed awake until 5:30 AM before taking a benadryl. After consulting my doctor we identified effective medications. I'll stay on those until I hit my goal or maintenance phase, and I'm hoping the insomnia eases by then.

ClearCinder32archiveFeb 2

My sleep was already bad before starting Tirzepatide, so I can't tell if it worsened, though the reduced calories made it more obvious. I talked to my doctor about adding a sleep aid and got a mild prescription, but then switched to something else that's less expensive and equally effective.

RustHarbour93archiveFeb 2
↳ replying to @SteadyThistle59 (opening post)

Right now it's four in the morning and rest has completely escaped me. One decent stretch of slumber hits maybe once every seven days. On the other nights I manage only a couple of hours, and roughly every ten days I end up awake the whole time. Since I'm no longer working the lack of rest doesn't create much trouble, though I still needed to tell my spouse that nothing serious is happening and the medications are responsible. I wonder whether that's accurate, especially since others mention the same pattern. After changing over from the prior treatment a short while back I'm counting on things settling down. Even the sleep prescriptions I already take get overpowered by whatever this is doing.

WarmMarble59archiveFeb 2

This is a side note, but I deal with sleep apnea and insert the data card from my breathing device into analysis software each day to review the readings. After beginning the medication, the device started registering more instances of what it labels as central apneas, and this pattern has continued over the past year. These devices aren't able to accurately identify true central events, where the brain stops signaling for breathing rather than a physical blockage, yet it suggests that the drug is easing my breathing muscles somehow, extending the pause after exhaling before the next breath in. My overall index scores remain solid, though I notice the machine doesn't work quite as well now compared to initially. Still, this could be coincidental.

BlueSparrow84archiveFeb 20

Truth is, I'm going through the complete reverse and dealing with serious exhaustion. My work involves night shifts, so I'm not inclined to hold the medication fully responsible, but right after the previous dose I slept nonstop for two days.

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