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I’m looking for some advice.

17 replies10 peopleSep 14, 2026☆ Follow
Summary

how to stack tirzepatide with cagrilintide retatrutide or elora to keep losing weight without worsening mental health side effects

the original poster is at 7 mg tirzepatide and stalled after losing 18 kg, having backed off higher doses due to emotional side effects. several users report adding low-dose cagrilintide or switching to or layering retatrutide with mixed results on hunger and mood. others prefer waiting for elora and note that split dosing or slower titration can sometimes reduce side effects without changing the total weekly amount.

What this discussion establishesWhere people disagree

whether adding retatrutide to existing tirzepatide is useful versus switching entirely or waiting for elora instead

Still open

long-term safety and optimal dosing when combining these compounds

Nothing here is advice.

17 replies · 10 people
RustHarbour63archiveopening postSep 14

i'm on 7 mg tirzepatide and don't want to raise it because higher amounts hurt my mental health. i'd like to add something else, preferably elora even though its safety isn't clear yet. i thought about cagrilintide earlier but now lean toward retatrutide instead. any thoughts on side effects and cost? i'm at 85 kg after dropping 18 kg since november with solid fat loss and muscle gain, but the scale has slowed and i still want to lose another 18-20 kg.

NorthAnchor41archiveSep 14

i added cagrilintide to tirzepatide when i was at 8 mg because food noise was returning even though weight loss was still happening. i started at 100 mcg and increased slowly. i've been on the combination for two years now and am currently at 15 mg tirzepatide with 3 mg cagrilintide. i'll probably move to elora once it's easier to get. stacking tirzepatide with retatrutide might only add the glucagon effect, so switching fully to retatrutide first could help check how it affects mental health before combining anything.

WryHarbour43archiveSep 14

what exactly happened with mental health at higher tirzepatide doses? how long were you on the previous amount, how big were the jumps, and how long did you stay at each level? how long have you been back at 7 mg and did the effects ease? when you say progress is slower, are you still losing a little or completely flat, and for how long? how strong is the appetite control right now? past reactions don't mean it will happen again, and your body might handle increases better now. splitting the dose could be worth trying if you haven't already.

AmberCinder46archiveSep 14

starting with a low dose of cagrilintide would be the cheapest route. my short try with it wasn't great so i switched to elora instead. the right mix is different for everyone and part of the fun is figuring it out.

SteadySparrow75archiveSep 14
↳ replying to @AmberCinder46

adding sema would probably be the cheapest option since it can quiet hunger quite effectively too.

RustHarbour63archiveSep 14

i stayed at 5 mg for a long time. when it stopped working as well i raised by 0.5 mg every four weeks because i wanted to lose as much as possible before turning 60. after that birthday i decided to slow down. at 7 mg with shots every six days i felt very emotional for a day or two and got embarrassed easily at work, so i dropped back to 6.5 mg. i then crept up more slowly to 7 mg every seven days and the mood dip was milder, just one afternoon on a sunday. weight is basically flat now, sometimes down half a kilo and sometimes up a bit, and i don't feel ready for bigger jumps.

AmberCinder46archiveSep 14
↳ replying to @SteadySparrow75

i've never tried sema. from what i've read the side effects are stronger than with tirzepatide, and stacking it on top might be overkill anyway.

SteadySparrow75archiveSep 14
↳ replying to @AmberCinder46

plenty of people have used sema the same way as cagrilintide, either occasionally or as a regular part of a stack. i bought some for exactly that purpose as a hunger or plateau breaker, though i haven't used it yet. it's just another possibility.

RustHarbour63archiveSep 14

sema isn't my top choice. splitting tirzepatide to 4 mg every four days is another possibility. i'm also waiting on elora and want to add ghk-cu along with possibly bpc.

BrightCinder50archiveSep 14
↳ replying to @RustHarbour63 (opening post)

i was on tirzepatide alone and ran into side effects at higher doses so i added retatrutide instead. it seems to be working with fewer issues than tirzepatide by itself. right now i'm at 2.5 mg tirzepatide and 1.5 mg retatrutide.

RustHarbour63archiveSep 14

how is the weight loss and food noise going with that approach?

LevelAlder29archiveSep 14
↳ replying to @RustHarbour63 (opening post)

translation of the earlier posts: stayed at 5 mg long term then raised slowly by half milligrams. mood effects hit even with tiny increases. weight is now flat. sema not first choice. splitting tirzepatide or waiting for elora are options. also considering adding ghk-cu and possibly bpc. elora will likely be the most expensive choice.

WryHarbour43archiveSep 15
↳ replying to @RustHarbour63

those dose steps were much smaller than the trials used, so it's interesting the mood difference was still noticeable. do you track food intake? low blood sugar from big drops in eating right after a shot could also affect mood. even at the reduced pace you're still seeing some mood impact, which might support trying split dosing to even things out. adding another compound is reasonable too. curious what you end up trying.

the actual study data isn't fully released yet, only some early numbers from the company, and they followed the usual four-week steps with the standard 2.5 to 15 mg increases.

IronKettle95archive5d
↳ replying to @CopperSignal27

the titration schedule makes the results even more striking since the average dose was only around 8.75 mg during the first six months. hoping the study keeps going to see what happens next. i decided to try elora myself before reaching goal and it should replace the cagrilintide i'm currently using.

IronLantern24archive5d
↳ replying to @RustHarbour63 (opening post)

tirzepatide is supposed to be stronger on appetite control. retatrutide started affecting my mental health once i reached 6 mg, which is why i'm planning to add tirzepatide and lower the retatrutide dose. a small amount of retatrutide added to tirzepatide might work better for you instead.

↳ replying to @IronKettle95

those early numbers look like some of the strongest results seen with any glp compound, close to the retatrutide data but over a longer time. there's a good chance low-dose tirzepatide or retatrutide plus low-dose elora could give the best loss with the fewest sides for people who aren't extremely obese. many here seem to be testing that approach. elora appeared to add more loss on top of tirzepatide than cagrilintide did. full results after longer follow-up will be interesting, though cost would be high without grey-market versions.

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